Revisionist look at solvophobic driving forces in reversed-phase liquid chromatography. II. Partitioning vs. adsorption mechanism in monomeric alkyl bonded phase supports

Lay Choo Tan; Peter W. Carr

doi:10.1016/S0021-9673(97)00228-8

Revisionist look at solvophobic driving forces in reversed-phase liquid chromatography. II. Partitioning vs. adsorption mechanism in monomeric alkyl bonded phase supports

Lay Choo Tan, Peter W. Carr

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

The partitioning and absorption mechanisms of retention in reversed-phase liquid chromtography (RPLC) were examined based on the free energy of transfer of a methylene group from organic aqueous mixtures to bulk hexadecane. Retention on monomeric bonded phases with octyl chains or longer are dominated by a partitioning-like mechanism. An adsorption-like mechanism contributes to retention in monomeric bonded phases with short bonded chains or with low surface coverage density. The retention mechanism becomes more adsorption-like as the bonded chains decrease.

Original language	English (US)
Pages (from-to)	1-12
Number of pages	12
Journal	Journal of Chromatography A
Volume	775
Issue number	1-2
DOIs	https://doi.org/10.1016/S0021-9673(97)00228-8
State	Published - Jul 18 1997

Bibliographical note

Funding Information:
This work was supported by a grant from the National Science Foundation.

Keywords

Adsorption
Partitioning
Retention mechanisms
Solvophobic theory
Stationary phases, LC

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AU - Carr, Peter W.

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Y1 - 1997/7/18

N2 - The partitioning and absorption mechanisms of retention in reversed-phase liquid chromtography (RPLC) were examined based on the free energy of transfer of a methylene group from organic aqueous mixtures to bulk hexadecane. Retention on monomeric bonded phases with octyl chains or longer are dominated by a partitioning-like mechanism. An adsorption-like mechanism contributes to retention in monomeric bonded phases with short bonded chains or with low surface coverage density. The retention mechanism becomes more adsorption-like as the bonded chains decrease.

AB - The partitioning and absorption mechanisms of retention in reversed-phase liquid chromtography (RPLC) were examined based on the free energy of transfer of a methylene group from organic aqueous mixtures to bulk hexadecane. Retention on monomeric bonded phases with octyl chains or longer are dominated by a partitioning-like mechanism. An adsorption-like mechanism contributes to retention in monomeric bonded phases with short bonded chains or with low surface coverage density. The retention mechanism becomes more adsorption-like as the bonded chains decrease.

KW - Adsorption

KW - Partitioning

KW - Retention mechanisms

KW - Solvophobic theory

KW - Stationary phases, LC

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Revisionist look at solvophobic driving forces in reversed-phase liquid chromatography. II. Partitioning vs. adsorption mechanism in monomeric alkyl bonded phase supports

Abstract

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Keywords

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