Rheological and biochemical properties of middle ear effusions from experimental otitis media in cats

Kazuhiko Takeuchi, Yukiyoshi Hamaguchi, Yuichi Majima, Chun Shun Jin, Yasuo Sakakura, Steven K. Juhn

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Both rheological and biochemical analyses were performed on middle ear effusions (MEEs) from cats with experimental otitis media with effusions (OME) induced by obstruction of the Eustachian tube. This study was undertaken in order to clarify the factors determining rheological properties (elasticity and viscosity) of MEEs. The viscoelasticity of the effusions had a positive significant correlation to fucose/total protein concentration (TPC), and a negative correlation to cathepsin B level/TPC. No correlation was observed between albumin level/TPC and viscoelasticity. These results indicate that in cats the rheological properties of MEEs depend on the level of secretory glycoproteins in MEEs and on the severity of inflammation in the early stage after tubal obstruction.

Original languageEnglish (US)
Pages (from-to)17-22
Number of pages6
JournalActa Oto-Laryngologica
Volume111
Issue numberS483
DOIs
StatePublished - 1991

Bibliographical note

Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research (B) 62480355 from the Ministry of Education, Science and Culture of Japan.

Keywords

  • Cathepsin B
  • Elasticity
  • Fucose
  • Otitis media with effusion
  • Viscosity

Fingerprint

Dive into the research topics of 'Rheological and biochemical properties of middle ear effusions from experimental otitis media in cats'. Together they form a unique fingerprint.

Cite this