Rhodium(II)-catalyzed c-h functionalization of electron-deficient methyl groups

Liangbing Fu, David M. Guptill, Huw M.L. Davies

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Enantioselective C-H functionalization of relatively electron-deficient methyl sites was achieved with the combination of 2,2,2-trichloroethyl aryldiazoacetates and tetrakis(triarylcyclopropanecarboxylate) dirhodium catalysts. The substrate scope of the transformation was relatively broad, and C-H functionalization products were furnished with excellent levels of enantioselectivity. As a strategic reaction, crotonate derivatives give 1,6-dicarbonyl compounds, which are useful for further diversification.

Original languageEnglish (US)
Pages (from-to)5761-5764
Number of pages4
JournalJournal of the American Chemical Society
Volume138
Issue number18
DOIs
StatePublished - May 11 2016

Bibliographical note

Publisher Copyright:
© 2016 American Chemical Society.

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