Rich club analysis of structural brain connectivity at 7 tesla versus 3 tesla

Emily L. Dennis, Liang Zhan, Neda Jahanshad, Bryon A. Mueller, Yan Jin, Christophe Lenglet, Essa Yacoub, Guillermo Sapiro, Kamil Ugurbil, Noam Harel, Arthurw Toga, Kelvin O. Lim, Paul M. Thompson

Research output: Contribution to journalConference articlepeer-review

3 Scopus citations


The ‘rich club’ is a relatively new concept in brain connectivity analysis, which identifies a core of densely interconnected high-degree nodes. Establishing normative measures for rich club organization is vital, as is understanding how scanning parameters affect it.We compared the rich club organization in 23 subjects scanned at both 7 and 3 T, with 128-gradient high angular resolution diffusion imaging (HARDI). The rich club coefficient (RCC) did not differ significantly between low and high field scans, but the field strength did affect which nodes were included in the rich club. We also examined 3 subjects with Alzheimer’s disease and 3 healthy elderly controls to see how field strength affected the statistical comparison. RCC did not differ with field strength, but again, which nodes differed between groups did. These results illustrate how one key parameter, scanner field strength, impacts rich club organization – a promising concept in brain connectomics research.

Original languageEnglish (US)
Pages (from-to)209-218
Number of pages10
JournalMathematics and Visualization
StatePublished - 2014
Event16th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2013 - Nagoya, Japan
Duration: Sep 22 2013Sep 26 2013


  • 7T
  • Alzheimer’s
  • Connectivity
  • Connectome
  • DTI
  • Field strength
  • Rich club
  • Tractography


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