RIFM fragrance ingredient safety assessment, α-Ionone, CAS Registry Number 127-41-3

A. M. Api; D. Belsito; S. Bhatia; M. Bruze; P. Calow; M. L. Dagli; W. Dekant; A. D. Fryer; L. Kromidas; S. La Cava; J. F. Lalko; A. Lapczynski; D. C. Liebler; Y. Miyachi; V. T. Politano; G. Ritacco; D. Salvito; T. W. Schultz; J. Shen; I. G. Sipes; B. Wall; D. K. Wilcox

doi:10.1016/j.fct.2015.12.010

RIFM fragrance ingredient safety assessment, α-Ionone, CAS Registry Number 127-41-3

A. M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava, J. F. Lalko, A. Lapczynski, D. C. Liebler, Y. Miyachi, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. Shen, I. G. SipesB. Wall, D. K. Wilcox

Research output: Contribution to journal › Short survey › peer-review

8 Scopus citations

Abstract

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 10 mg/kg/day. A dietary 90-day subchronic toxicity study conducted in rats resulted in a MOE of 182 while assuming 100% absorption from skin contact and inhalation. A MOE of >100 is deemed acceptable.

Original language	English (US)
Pages (from-to)	S1-S10
Journal	Food and Chemical Toxicology
Volume	97
DOIs	https://doi.org/10.1016/j.fct.2015.12.010
State	Published - Nov 1 2016

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Ltd

Keywords

Developmental and reproductive toxicity
Environmental safety
Genotoxicity
Local respiratory toxicity
Phototoxicity and photoallergenicity
Repeated dose
Skin sensitization

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Api, A. M., Belsito, D., Bhatia, S., Bruze, M., Calow, P., Dagli, M. L., Dekant, W., Fryer, A. D., Kromidas, L., La Cava, S., Lalko, J. F., Lapczynski, A., Liebler, D. C., Miyachi, Y., Politano, V. T., Ritacco, G., Salvito, D., Schultz, T. W., Shen, J., ... Wilcox, D. K. (2016). RIFM fragrance ingredient safety assessment, α-Ionone, CAS Registry Number 127-41-3. Food and Chemical Toxicology, 97, S1-S10. https://doi.org/10.1016/j.fct.2015.12.010

Api, AM, Belsito, D, Bhatia, S, Bruze, M, Calow, P, Dagli, ML, Dekant, W, Fryer, AD, Kromidas, L, La Cava, S, Lalko, JF, Lapczynski, A, Liebler, DC, Miyachi, Y, Politano, VT, Ritacco, G, Salvito, D, Schultz, TW, Shen, J, Sipes, IG, Wall, B & Wilcox, DK 2016, 'RIFM fragrance ingredient safety assessment, α-Ionone, CAS Registry Number 127-41-3', Food and Chemical Toxicology, vol. 97, pp. S1-S10. https://doi.org/10.1016/j.fct.2015.12.010

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abstract = "The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 10 mg/kg/day. A dietary 90-day subchronic toxicity study conducted in rats resulted in a MOE of 182 while assuming 100% absorption from skin contact and inhalation. A MOE of >100 is deemed acceptable.",

keywords = "Developmental and reproductive toxicity, Environmental safety, Genotoxicity, Local respiratory toxicity, Phototoxicity and photoallergenicity, Repeated dose, Skin sensitization",

author = "Api, {A. M.} and D. Belsito and S. Bhatia and M. Bruze and P. Calow and Dagli, {M. L.} and W. Dekant and Fryer, {A. D.} and L. Kromidas and {La Cava}, S. and Lalko, {J. F.} and A. Lapczynski and Liebler, {D. C.} and Y. Miyachi and Politano, {V. T.} and G. Ritacco and D. Salvito and Schultz, {T. W.} and J. Shen and Sipes, {I. G.} and B. Wall and Wilcox, {D. K.}",

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doi = "10.1016/j.fct.2015.12.010",

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AU - Api, A. M.

AU - Belsito, D.

AU - Bhatia, S.

AU - Bruze, M.

AU - Calow, P.

AU - Dagli, M. L.

AU - Dekant, W.

AU - Fryer, A. D.

AU - Kromidas, L.

AU - La Cava, S.

AU - Lalko, J. F.

AU - Lapczynski, A.

AU - Liebler, D. C.

AU - Miyachi, Y.

AU - Politano, V. T.

AU - Ritacco, G.

AU - Salvito, D.

AU - Schultz, T. W.

AU - Shen, J.

AU - Sipes, I. G.

AU - Wall, B.

AU - Wilcox, D. K.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 10 mg/kg/day. A dietary 90-day subchronic toxicity study conducted in rats resulted in a MOE of 182 while assuming 100% absorption from skin contact and inhalation. A MOE of >100 is deemed acceptable.

AB - The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 10 mg/kg/day. A dietary 90-day subchronic toxicity study conducted in rats resulted in a MOE of 182 while assuming 100% absorption from skin contact and inhalation. A MOE of >100 is deemed acceptable.

KW - Developmental and reproductive toxicity

KW - Environmental safety

KW - Genotoxicity

KW - Local respiratory toxicity

KW - Phototoxicity and photoallergenicity

KW - Repeated dose

KW - Skin sensitization

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U2 - 10.1016/j.fct.2015.12.010

DO - 10.1016/j.fct.2015.12.010

M3 - Short survey

C2 - 26702988

AN - SCOPUS:84997447780

SN - 0278-6915

VL - 97

SP - S1-S10

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

ER -

RIFM fragrance ingredient safety assessment, α-Ionone, CAS Registry Number 127-41-3

Abstract

Bibliographical note

Keywords

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