RIFM fragrance ingredient safety assessment, benzyl butyrate, CAS Registry Number 103-37-7

A. M. Api; D. Belsito; S. Bhatia; M. Bruze; P. Calow; M. L. Dagli; W. Dekant; A. D. Fryer; L. Kromidas; S. La Cava; J. F. Lalko; A. Lapczynski; D. C. Liebler; V. T. Politano; G. Ritacco; D. Salvito; T. W. Schultz; J. Shen; I. G. Sipes; B. Wall; D. K. Wilcox

doi:10.1016/j.fct.2016.08.007

RIFM fragrance ingredient safety assessment, benzyl butyrate, CAS Registry Number 103-37-7

A. M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava, J. F. Lalko, A. Lapczynski, D. C. Liebler, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. Shen, I. G. Sipes, B. WallD. K. Wilcox

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Abstract

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog benzyl acetate (CAS # 140-11-4) show that this material is not genotoxic nor does it have skin sensitization potential and also provided a MOE > 100 for the repeated dose, developmental and reproductive, and local respiratory toxicity endpoints. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

Original language	English (US)
Pages (from-to)	S136-S146
Journal	Food and Chemical Toxicology
Volume	97
DOIs	https://doi.org/10.1016/j.fct.2016.08.007
State	Published - Nov 1 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ltd

Keywords

Developmental and reproductive Toxicity
Environmental safety
Genotoxicity
Local respiratory toxicity
Phototoxicity/photoallergenicity
Repeated dose
Skin sensitization

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Api, A. M., Belsito, D., Bhatia, S., Bruze, M., Calow, P., Dagli, M. L., Dekant, W., Fryer, A. D., Kromidas, L., La Cava, S., Lalko, J. F., Lapczynski, A., Liebler, D. C., Politano, V. T., Ritacco, G., Salvito, D., Schultz, T. W., Shen, J., Sipes, I. G., ... Wilcox, D. K. (2016). RIFM fragrance ingredient safety assessment, benzyl butyrate, CAS Registry Number 103-37-7. Food and Chemical Toxicology, 97, S136-S146. https://doi.org/10.1016/j.fct.2016.08.007

Api, AM, Belsito, D, Bhatia, S, Bruze, M, Calow, P, Dagli, ML, Dekant, W, Fryer, AD, Kromidas, L, La Cava, S, Lalko, JF, Lapczynski, A, Liebler, DC, Politano, VT, Ritacco, G, Salvito, D, Schultz, TW, Shen, J, Sipes, IG, Wall, B & Wilcox, DK 2016, 'RIFM fragrance ingredient safety assessment, benzyl butyrate, CAS Registry Number 103-37-7', Food and Chemical Toxicology, vol. 97, pp. S136-S146. https://doi.org/10.1016/j.fct.2016.08.007

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AU - Bruze, M.

AU - Calow, P.

AU - Dagli, M. L.

AU - Dekant, W.

AU - Fryer, A. D.

AU - Kromidas, L.

AU - La Cava, S.

AU - Lalko, J. F.

AU - Lapczynski, A.

AU - Liebler, D. C.

AU - Politano, V. T.

AU - Ritacco, G.

AU - Salvito, D.

AU - Schultz, T. W.

AU - Shen, J.

AU - Sipes, I. G.

AU - Wall, B.

AU - Wilcox, D. K.

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N2 - The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog benzyl acetate (CAS # 140-11-4) show that this material is not genotoxic nor does it have skin sensitization potential and also provided a MOE > 100 for the repeated dose, developmental and reproductive, and local respiratory toxicity endpoints. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

AB - The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog benzyl acetate (CAS # 140-11-4) show that this material is not genotoxic nor does it have skin sensitization potential and also provided a MOE > 100 for the repeated dose, developmental and reproductive, and local respiratory toxicity endpoints. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

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RIFM fragrance ingredient safety assessment, benzyl butyrate, CAS Registry Number 103-37-7

Abstract

Bibliographical note

Keywords

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