Ring of Power: A Band of Peptidergic Midbrain Neurons that Binds Motivation

Research output: Contribution to journalShort surveypeer-review

Abstract

A recent Cell paper identifies a novel population of neurons within the ventral tegmental area producing the endogenous opioid nociceptin that regulates dopamine neuron firing and acts uniquely to gate motivation in reward seeking. These results highlight neuropeptidergic signaling as a critical component of functional heterogeneity in the midbrain.

Original languageEnglish (US)
Pages (from-to)364-366
Number of pages3
JournalNeuron
Volume103
Issue number3
DOIs
StatePublished - Aug 7 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

  • dopamine
  • fiber photometry
  • nociceptin
  • opioids
  • reward
  • ventral tegmental area

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