Risk factors for abnormal cervical cytology in women undergoing kidney transplant evaluation

Kevin V. Chaung; Yu Zheng; Anthony T. Martella; Jordan B. Stoecker; Devan R. Cote; Joshua J. Augustine; Edmund Q. Sanchez; Vanessa R. Humphreville; John B. Ammori; Kenneth J. Woodside

doi:10.6002/ect.2017.0064

Risk factors for abnormal cervical cytology in women undergoing kidney transplant evaluation

Kevin V. Chaung, Yu Zheng, Anthony T. Martella, Jordan B. Stoecker, Devan R. Cote, Joshua J. Augustine, Edmund Q. Sanchez, Vanessa R. Humphreville, John B. Ammori, Kenneth J. Woodside

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Abstract

Objectives: Cervical cytology screening has been successful in reducing deaths from cervical cancer. We sought to determine risk factors for abnormal Pap test results in women undergoing kidney transplant evaluation. Materials and Methods: We retrospectively examined women undergoing kidney transplant evaluations from 2008 to 2011. Patients were stratified based on normal cytology and atypical/malignant cytology. Results: Of 404 patients, 293 patients (72.5%) had normal cytologic findings, whereas 111 (27.5%) had abnormal findings. On univariate logistic regression analyses, patients who had chronic kidney disease with an autoimmune cause (odds ratio = 2.71 [95% confidence interval, 1.41-5.19]; P =.003), previous renal transplants (odds ratio = 2.64 [95% confidence interval, 1.20-5.82], P =.016), or age ≤ 50 years (odds ratio = 1.68 [95% confidence interval, 1.08-2.61], P =.022) were more likely to have abnormal findings. Patients with normal and abnormal findings had similar rates of dialysis use. On multivariate logistic regression, patients who had chronic kidney disease with autoimmune causes (odds ratio = 2.48 [95% confidence interval, 1.26-4.88]; P =.008) and who had previous renal transplants (odds ratio = 2.67 [95% confidence interval, 1.20-5.95]; P =.017) were more likely to have abnormal findings. Conclusions: Previous kidney transplant, autoimmune disease, and age ≤ 50 years were associated with abnormalities on cervical cancer screening in our female group of patients. Patients with these characteristics may benefit more from routine cervical cancer screening than other patients evaluated for kidney transplant.

Original language	English (US)
Pages (from-to)	31-36
Number of pages	6
Journal	Experimental and Clinical Transplantation
Volume	17
Issue number	1
DOIs	https://doi.org/10.6002/ect.2017.0064
State	Published - Feb 2019
Externally published	Yes

Bibliographical note

Funding Information:
From the the 1Division of Transplant Surgery, Department of Surgery, the 2Division of Nephrology, Department of Internal Medicine, and the 3Division of General and Oncologic Surgery, Department of Surgery, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA; and the 4Section of Transplantation Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA Acknowledgements: This study was supported by the Office of Medical Education and Committee of Student Representatives at Case Western Reserve University School of Medicine. The authors have no conflicts of interest to report. We thank Kelly Noon and Genevieve Popp for database assistance. Corresponding author: Kenneth J. Woodside, Section of Transplant Surgery, Department of Surgery, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-5296, USA Phone: +1 734 936 8363 E-mail: woodside@umich.edu

Publisher Copyright:
© Başkent University 2019.

Keywords

Cancer screening
Cervical cancer
Cervical cytology screening
Chronic kidney disease
End-stage renal disease
Kidney transplant evaluation

PubMed: MeSH publication types

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@article{e71b9149b23e4b5f9813079d2035ddca,

title = "Risk factors for abnormal cervical cytology in women undergoing kidney transplant evaluation",

abstract = "Objectives: Cervical cytology screening has been successful in reducing deaths from cervical cancer. We sought to determine risk factors for abnormal Pap test results in women undergoing kidney transplant evaluation. Materials and Methods: We retrospectively examined women undergoing kidney transplant evaluations from 2008 to 2011. Patients were stratified based on normal cytology and atypical/malignant cytology. Results: Of 404 patients, 293 patients (72.5%) had normal cytologic findings, whereas 111 (27.5%) had abnormal findings. On univariate logistic regression analyses, patients who had chronic kidney disease with an autoimmune cause (odds ratio = 2.71 [95% confidence interval, 1.41-5.19]; P =.003), previous renal transplants (odds ratio = 2.64 [95% confidence interval, 1.20-5.82], P =.016), or age ≤ 50 years (odds ratio = 1.68 [95% confidence interval, 1.08-2.61], P =.022) were more likely to have abnormal findings. Patients with normal and abnormal findings had similar rates of dialysis use. On multivariate logistic regression, patients who had chronic kidney disease with autoimmune causes (odds ratio = 2.48 [95% confidence interval, 1.26-4.88]; P =.008) and who had previous renal transplants (odds ratio = 2.67 [95% confidence interval, 1.20-5.95]; P =.017) were more likely to have abnormal findings. Conclusions: Previous kidney transplant, autoimmune disease, and age ≤ 50 years were associated with abnormalities on cervical cancer screening in our female group of patients. Patients with these characteristics may benefit more from routine cervical cancer screening than other patients evaluated for kidney transplant.",

keywords = "Cancer screening, Cervical cancer, Cervical cytology screening, Chronic kidney disease, End-stage renal disease, Kidney transplant evaluation",

author = "Chaung, {Kevin V.} and Yu Zheng and Martella, {Anthony T.} and Stoecker, {Jordan B.} and Cote, {Devan R.} and Augustine, {Joshua J.} and Sanchez, {Edmund Q.} and Humphreville, {Vanessa R.} and Ammori, {John B.} and Woodside, {Kenneth J.}",

note = "Funding Information: From the the 1Division of Transplant Surgery, Department of Surgery, the 2Division of Nephrology, Department of Internal Medicine, and the 3Division of General and Oncologic Surgery, Department of Surgery, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA; and the 4Section of Transplantation Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA Acknowledgements: This study was supported by the Office of Medical Education and Committee of Student Representatives at Case Western Reserve University School of Medicine. The authors have no conflicts of interest to report. We thank Kelly Noon and Genevieve Popp for database assistance. Corresponding author: Kenneth J. Woodside, Section of Transplant Surgery, Department of Surgery, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-5296, USA Phone: +1 734 936 8363 E-mail: woodside@umich.edu Publisher Copyright: {\textcopyright} Ba{\c s}kent University 2019.",

year = "2019",

month = feb,

doi = "10.6002/ect.2017.0064",

language = "English (US)",

volume = "17",

pages = "31--36",

journal = "Experimental and Clinical Transplantation",

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publisher = "American Chemical Society",

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TY - JOUR

T1 - Risk factors for abnormal cervical cytology in women undergoing kidney transplant evaluation

AU - Chaung, Kevin V.

AU - Zheng, Yu

AU - Martella, Anthony T.

AU - Stoecker, Jordan B.

AU - Cote, Devan R.

AU - Augustine, Joshua J.

AU - Sanchez, Edmund Q.

AU - Humphreville, Vanessa R.

AU - Ammori, John B.

AU - Woodside, Kenneth J.

N1 - Funding Information: From the the 1Division of Transplant Surgery, Department of Surgery, the 2Division of Nephrology, Department of Internal Medicine, and the 3Division of General and Oncologic Surgery, Department of Surgery, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA; and the 4Section of Transplantation Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA Acknowledgements: This study was supported by the Office of Medical Education and Committee of Student Representatives at Case Western Reserve University School of Medicine. The authors have no conflicts of interest to report. We thank Kelly Noon and Genevieve Popp for database assistance. Corresponding author: Kenneth J. Woodside, Section of Transplant Surgery, Department of Surgery, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-5296, USA Phone: +1 734 936 8363 E-mail: woodside@umich.edu Publisher Copyright: © Başkent University 2019.

PY - 2019/2

Y1 - 2019/2

N2 - Objectives: Cervical cytology screening has been successful in reducing deaths from cervical cancer. We sought to determine risk factors for abnormal Pap test results in women undergoing kidney transplant evaluation. Materials and Methods: We retrospectively examined women undergoing kidney transplant evaluations from 2008 to 2011. Patients were stratified based on normal cytology and atypical/malignant cytology. Results: Of 404 patients, 293 patients (72.5%) had normal cytologic findings, whereas 111 (27.5%) had abnormal findings. On univariate logistic regression analyses, patients who had chronic kidney disease with an autoimmune cause (odds ratio = 2.71 [95% confidence interval, 1.41-5.19]; P =.003), previous renal transplants (odds ratio = 2.64 [95% confidence interval, 1.20-5.82], P =.016), or age ≤ 50 years (odds ratio = 1.68 [95% confidence interval, 1.08-2.61], P =.022) were more likely to have abnormal findings. Patients with normal and abnormal findings had similar rates of dialysis use. On multivariate logistic regression, patients who had chronic kidney disease with autoimmune causes (odds ratio = 2.48 [95% confidence interval, 1.26-4.88]; P =.008) and who had previous renal transplants (odds ratio = 2.67 [95% confidence interval, 1.20-5.95]; P =.017) were more likely to have abnormal findings. Conclusions: Previous kidney transplant, autoimmune disease, and age ≤ 50 years were associated with abnormalities on cervical cancer screening in our female group of patients. Patients with these characteristics may benefit more from routine cervical cancer screening than other patients evaluated for kidney transplant.

AB - Objectives: Cervical cytology screening has been successful in reducing deaths from cervical cancer. We sought to determine risk factors for abnormal Pap test results in women undergoing kidney transplant evaluation. Materials and Methods: We retrospectively examined women undergoing kidney transplant evaluations from 2008 to 2011. Patients were stratified based on normal cytology and atypical/malignant cytology. Results: Of 404 patients, 293 patients (72.5%) had normal cytologic findings, whereas 111 (27.5%) had abnormal findings. On univariate logistic regression analyses, patients who had chronic kidney disease with an autoimmune cause (odds ratio = 2.71 [95% confidence interval, 1.41-5.19]; P =.003), previous renal transplants (odds ratio = 2.64 [95% confidence interval, 1.20-5.82], P =.016), or age ≤ 50 years (odds ratio = 1.68 [95% confidence interval, 1.08-2.61], P =.022) were more likely to have abnormal findings. Patients with normal and abnormal findings had similar rates of dialysis use. On multivariate logistic regression, patients who had chronic kidney disease with autoimmune causes (odds ratio = 2.48 [95% confidence interval, 1.26-4.88]; P =.008) and who had previous renal transplants (odds ratio = 2.67 [95% confidence interval, 1.20-5.95]; P =.017) were more likely to have abnormal findings. Conclusions: Previous kidney transplant, autoimmune disease, and age ≤ 50 years were associated with abnormalities on cervical cancer screening in our female group of patients. Patients with these characteristics may benefit more from routine cervical cancer screening than other patients evaluated for kidney transplant.

KW - Cancer screening

KW - Cervical cancer

KW - Cervical cytology screening

KW - Chronic kidney disease

KW - End-stage renal disease

KW - Kidney transplant evaluation

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Risk factors for abnormal cervical cytology in women undergoing kidney transplant evaluation

Abstract

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Keywords

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UN SDGs

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