Risk factors for cardiovascular disease after renal transplantation

B. L. Kasiske

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations

Abstract

The incidence of cardiovascular disease is high after renal transplantation. Risk factors include pretransplant cardiovascular disease, diabetes, male sex, serum cholesterol, hypertension, cigarette smoking, and allograft dysfunction. Prevention of cardiovascular disease can probably best be approached by modifying multiple risk factors. Thus, efforts should be made to identify and treat patients with severe coronary artery disease before transplantation. After transplantation, hypertension and hyperlipidemia should be treated, and efforts should be made to help patients abstain from smoking. Chronic immunosuppression protocols should attempt to balance the need to prevent allograft rejection with the known adverse effects of immunosuppressive agents on cardiovascular disease. Altogether, an aggressive, coordinated program to modify multiple risk factors is probably the best approach to the prevention of cardiovascular disease after renal transplantation.

Original languageEnglish (US)
Pages (from-to)186-195
Number of pages10
JournalMineral and Electrolyte Metabolism
Volume19
Issue number3
StatePublished - 1993

Bibliographical note

Funding Information:
Partially supported by Grant “Red Temática de Investigaciáon Cooperativa de Transplante” C03/03.

Copyright:
Copyright 2004 Elsevier B.V., All rights reserved.

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