Risk factors for heart attack, stroke, and venous thrombosis associated with hormonal contraceptive use

Marina Y. Zakharova, Rachel M. Meyer, Kyle R. Brandy, Yvonne H. Datta, Marilyn S. Joseph, Pamela J. Schreiner, Gundu H. Rao, Afshin A. Divani

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

The search for a safe and effective method of contraception has been ongoing for centuries. During the last century, a variety of hormonal contraceptives, including combined hormonal oral contraceptives (COCs), have been introduced into the market. COCs have evolved through modifications of different hormonal components to minimize the risk of thrombotic events including stroke, myocardial infarction, and venous thrombosis. The evolution of COC development led to the reduction in the estrogen dose, in an attempt to lower the risk of vascular diseases. Although the risk of thrombotic events due to COC use has been substantially reduced since their inception, the quest for developing safer methods of birth control continues. It is of great interest to study coagulation effects of newer COCs, as well as progestin only, as rigorously as older COCs.

Original languageEnglish (US)
Pages (from-to)323-331
Number of pages9
JournalClinical and Applied Thrombosis/Hemostasis
Volume17
Issue number4
DOIs
StatePublished - Aug 2011

Bibliographical note

Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.

Keywords

  • birth control
  • blood clot
  • heart attack
  • hormonal contraceptive
  • stroke
  • venous thrombus

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