TY - JOUR
T1 - Risk factors for in-stent restenosis after vertebral ostium stenting
AU - Taylor, Robert A.
AU - Siddiq, Farhan
AU - Suri, M. Fareed K.
AU - Martin, Coleman O.
AU - Hayakawa, Minako
AU - Chaloupka, John C.
PY - 2008/4/1
Y1 - 2008/4/1
N2 - Purpose: To determine whether vascular risk factors, underlying vessel diameter, and/or the type of stent affect restenosis rates for vertebral ostium stents. Methods: A single-center retrospective analysis was conducted of 44 patients (31 men; mean age 61 years, range 32-81) who underwent stenting of 48 ostial lesions in the vertebral arteries between 1999 and 2005. Only patients who underwent angiographic follow-up were included in the analysis. Cox regression analysis was utilized for risk factor association with binary restenosis (≥50% versus <50%). Stent types and stent categories were compared for differences in binary restenosis rates and lumen gain at follow-up angiography. Results: Twenty-three (48%) of 48 lesions had >50% stenosis at a mean follow-up of 7.7 months. Cigarette smoking was associated with higher binary restenosis rates (p=0.025), while hypertension, diabetes, hyperlipidemia, history of neck radiation, and known coronary artery and/or peripheral vascular disease were not. Reduced binary restenosis rates and improved lumen gain were seen in cobalt chromium balloon-expandable stents compared to non-cobalt chromium stents (p=0.002 and p=0.002, respectively), stainless steel balloon-expandable stents (p=0.005 and p=0.005), and the S670 stent (p=0.069 and p=0.069). The size of stent used was not associated with risk of restenosis (p=0.756). Conclusions: Cobalt chromium stents were associated with reduced restenosis, while smoking was associated with increased restenosis risk.
AB - Purpose: To determine whether vascular risk factors, underlying vessel diameter, and/or the type of stent affect restenosis rates for vertebral ostium stents. Methods: A single-center retrospective analysis was conducted of 44 patients (31 men; mean age 61 years, range 32-81) who underwent stenting of 48 ostial lesions in the vertebral arteries between 1999 and 2005. Only patients who underwent angiographic follow-up were included in the analysis. Cox regression analysis was utilized for risk factor association with binary restenosis (≥50% versus <50%). Stent types and stent categories were compared for differences in binary restenosis rates and lumen gain at follow-up angiography. Results: Twenty-three (48%) of 48 lesions had >50% stenosis at a mean follow-up of 7.7 months. Cigarette smoking was associated with higher binary restenosis rates (p=0.025), while hypertension, diabetes, hyperlipidemia, history of neck radiation, and known coronary artery and/or peripheral vascular disease were not. Reduced binary restenosis rates and improved lumen gain were seen in cobalt chromium balloon-expandable stents compared to non-cobalt chromium stents (p=0.002 and p=0.002, respectively), stainless steel balloon-expandable stents (p=0.005 and p=0.005), and the S670 stent (p=0.069 and p=0.069). The size of stent used was not associated with risk of restenosis (p=0.756). Conclusions: Cobalt chromium stents were associated with reduced restenosis, while smoking was associated with increased restenosis risk.
KW - Cobalt chromium stent
KW - Restenosis
KW - Stainless steel stent
KW - Vertebral ostial stenosis
KW - Vertebrobasilar stroke
UR - http://www.scopus.com/inward/record.url?scp=43049085885&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=43049085885&partnerID=8YFLogxK
U2 - 10.1583/07-2175.1
DO - 10.1583/07-2175.1
M3 - Article
C2 - 18426264
AN - SCOPUS:43049085885
SN - 1526-6028
VL - 15
SP - 203
EP - 212
JO - Journal of Endovascular Therapy
JF - Journal of Endovascular Therapy
IS - 2
ER -