Abstract
Ethanol (2 g/kg) reduces the time spent in social interaction and increases locomotor activity of pairs of NIH Swiss mice. This study examined whether two benzodiazepine receptor inverse agonists, RO 15-4513 (3 mg/kg) and FG 7142 (30 mg/kg) are able to reverse these effects. Neither drug alone altered social behavior, but both significantly attenuated the effect of ethanol on social interaction. They did not affect the ethanol-induced increase in motor activity. Benzodiazepine receptor inverse agonists thus appear capable of antagonizing some, but not all of the behavioral effects of ethanol in this paradigm.
Original language | English (US) |
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Pages (from-to) | 109-113 |
Number of pages | 5 |
Journal | European Journal of Pharmacology |
Volume | 154 |
Issue number | 1 |
DOIs | |
State | Published - Sep 1 1988 |
Externally published | Yes |
Keywords
- Benzodiazepine receptors
- Ethanol
- FG 7142
- Motor activity
- Ro 15-4513
- Social behavior