TY - GEN
T1 - Robust feature selection by weighted fisher criterion for multiclass prediction in gene expression profiling
AU - Xuan, Jianhua
AU - Dong, Yibin
AU - Khan, Javed
AU - Hoffman, Eric
AU - Clarke, Robert
AU - Wang, Yue
PY - 2004
Y1 - 2004
N2 - This paper presents a robust feature selection approach for multiclass prediction with application to microarray studies. First, individually discriminatory genes (IDGs) are identified by using weighted Fisher Criterion (wFC). Second, jointly discriminatory genes (JDGs) are selected by a sequential search method, according to their joint class separability. To combat the small size effect on feature selection, leave-one-out procedures are incorporated into both IDG and JDG selection steps to improve the robustness of the approach. By applying this approach to a microarray study of small round blue cell tumors (SRBCTs) of childhood, we have demonstrated that our robust feature selection method can be used to successfully identify a subset of genes with superior classification performance for multiclass prediction.
AB - This paper presents a robust feature selection approach for multiclass prediction with application to microarray studies. First, individually discriminatory genes (IDGs) are identified by using weighted Fisher Criterion (wFC). Second, jointly discriminatory genes (JDGs) are selected by a sequential search method, according to their joint class separability. To combat the small size effect on feature selection, leave-one-out procedures are incorporated into both IDG and JDG selection steps to improve the robustness of the approach. By applying this approach to a microarray study of small round blue cell tumors (SRBCTs) of childhood, we have demonstrated that our robust feature selection method can be used to successfully identify a subset of genes with superior classification performance for multiclass prediction.
UR - http://www.scopus.com/inward/record.url?scp=10044272925&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=10044272925&partnerID=8YFLogxK
U2 - 10.1109/ICPR.2004.1334170
DO - 10.1109/ICPR.2004.1334170
M3 - Conference contribution
AN - SCOPUS:10044272925
SN - 0769521282
T3 - Proceedings - International Conference on Pattern Recognition
SP - 291
EP - 294
BT - Proceedings of the 17th International Conference on Pattern Recognition, ICPR 2004
A2 - Kittler, J.
A2 - Petrou, M.
A2 - Nixon, M.
T2 - Proceedings of the 17th International Conference on Pattern Recognition, ICPR 2004
Y2 - 23 August 2004 through 26 August 2004
ER -