The role of EDNO in the PHT has been primarily evaluated in animals, with few human studies. Most research has focused on the chronic hypoxic form of PHT. With these limitations in mind, we conclude that basal pulmonary EDNO synthesis is preserved or increased in PHT. Although this EDNO up-regulation seems to reduce the severity of PHT, its relative importance among other modulating factors remains to be established.
|Original language||English (US)|
|Number of pages||11|
|Journal||Seminars in Respiratory and Critical Care Medicine|
|State||Published - Jan 1 1994|