Role of inter-trial phase coherence in atypical auditory evoked potentials to speech and nonspeech stimuli in children with autism

Luodi Yu; Suiping Wang; Dan Huang; Xueyuan Wu; Yang Zhang

doi:10.1016/j.clinph.2018.04.599

Role of inter-trial phase coherence in atypical auditory evoked potentials to speech and nonspeech stimuli in children with autism

Luodi Yu, Suiping Wang, Dan Huang, Xueyuan Wu, Yang Zhang

Speech-Language-Hearing Sciences

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Objective: This autism study investigated how inter-trial phase coherence (ITPC) drives abnormalities in auditory evoked potential (AEP) responses for speech and nonspeech stimuli. Methods: Auditory P1-N2 responses and ITPCs in the theta band (4–7 Hz) for pure tones and words were assessed with EEG data from 15 school-age children with autism and 16 age-matched typically developing (TD) controls. Results: The autism group showed enhanced P1 and reduced N2 for both speech and nonspeech stimuli in comparison with the TD group. Group differences were also found with enhanced theta ITPC for P1 followed by ITPC reduction for N2 in the autism group. The ITPC values were significant predictors of P1 and N2 amplitudes in both groups. Conclusions: Abnormal trial-to-trial phase synchrony plays an important role in AEP atypicalities in children with autism. ITPC-driven enhancement as well as attenuation in different AEP components may coexist, depending on the stage of information processing. Significance: It is necessary to examine the time course of auditory evoked potentials and the corresponding inter-trial coherence of neural oscillatory activities to better understand hyper- and hypo- sensitive responses in autism, which has important implications for sensory based treatment.

Original language	English (US)
Pages (from-to)	1374-1382
Number of pages	9
Journal	Clinical Neurophysiology
Volume	129
Issue number	7
DOIs	https://doi.org/10.1016/j.clinph.2018.04.599
State	Published - Jul 2018

Bibliographical note

Funding Information:
This work was supported by grants from the Natural Science Foundation of China (NSFC 31571136 ), Key Project of National Social Science Foundation of China ( 15AZD048 ), Key Project of National Natural Science Foundation of Guangdong Province ( 2014A030311016 ) to SW, and grants from the NSFC overseas collaboration grant (31728009), the Grand Challenges Exploratory Research Award, and CLA Brain Imaging Research Award of the University of Minnesota to YZ. We thank the participants and their families for their support, and Yang Fan, Xiaoyun Wu, Kai Fan for their assistance.

Publisher Copyright:
© 2018 International Federation of Clinical Neurophysiology

Keywords

Auditory evoked potential
Auditory processing
Autism
Inter-trial phase coherence
Speech perception

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

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title = "Role of inter-trial phase coherence in atypical auditory evoked potentials to speech and nonspeech stimuli in children with autism",

abstract = "Objective: This autism study investigated how inter-trial phase coherence (ITPC) drives abnormalities in auditory evoked potential (AEP) responses for speech and nonspeech stimuli. Methods: Auditory P1-N2 responses and ITPCs in the theta band (4–7 Hz) for pure tones and words were assessed with EEG data from 15 school-age children with autism and 16 age-matched typically developing (TD) controls. Results: The autism group showed enhanced P1 and reduced N2 for both speech and nonspeech stimuli in comparison with the TD group. Group differences were also found with enhanced theta ITPC for P1 followed by ITPC reduction for N2 in the autism group. The ITPC values were significant predictors of P1 and N2 amplitudes in both groups. Conclusions: Abnormal trial-to-trial phase synchrony plays an important role in AEP atypicalities in children with autism. ITPC-driven enhancement as well as attenuation in different AEP components may coexist, depending on the stage of information processing. Significance: It is necessary to examine the time course of auditory evoked potentials and the corresponding inter-trial coherence of neural oscillatory activities to better understand hyper- and hypo- sensitive responses in autism, which has important implications for sensory based treatment.",

keywords = "Auditory evoked potential, Auditory processing, Autism, Inter-trial phase coherence, Speech perception",

author = "Luodi Yu and Suiping Wang and Dan Huang and Xueyuan Wu and Yang Zhang",

note = "Funding Information: This work was supported by grants from the Natural Science Foundation of China (NSFC 31571136 ), Key Project of National Social Science Foundation of China ( 15AZD048 ), Key Project of National Natural Science Foundation of Guangdong Province ( 2014A030311016 ) to SW, and grants from the NSFC overseas collaboration grant (31728009), the Grand Challenges Exploratory Research Award, and CLA Brain Imaging Research Award of the University of Minnesota to YZ. We thank the participants and their families for their support, and Yang Fan, Xiaoyun Wu, Kai Fan for their assistance. Publisher Copyright: {\textcopyright} 2018 International Federation of Clinical Neurophysiology",

year = "2018",

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AU - Wang, Suiping

AU - Huang, Dan

AU - Wu, Xueyuan

AU - Zhang, Yang

N1 - Funding Information: This work was supported by grants from the Natural Science Foundation of China (NSFC 31571136 ), Key Project of National Social Science Foundation of China ( 15AZD048 ), Key Project of National Natural Science Foundation of Guangdong Province ( 2014A030311016 ) to SW, and grants from the NSFC overseas collaboration grant (31728009), the Grand Challenges Exploratory Research Award, and CLA Brain Imaging Research Award of the University of Minnesota to YZ. We thank the participants and their families for their support, and Yang Fan, Xiaoyun Wu, Kai Fan for their assistance. Publisher Copyright: © 2018 International Federation of Clinical Neurophysiology

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N2 - Objective: This autism study investigated how inter-trial phase coherence (ITPC) drives abnormalities in auditory evoked potential (AEP) responses for speech and nonspeech stimuli. Methods: Auditory P1-N2 responses and ITPCs in the theta band (4–7 Hz) for pure tones and words were assessed with EEG data from 15 school-age children with autism and 16 age-matched typically developing (TD) controls. Results: The autism group showed enhanced P1 and reduced N2 for both speech and nonspeech stimuli in comparison with the TD group. Group differences were also found with enhanced theta ITPC for P1 followed by ITPC reduction for N2 in the autism group. The ITPC values were significant predictors of P1 and N2 amplitudes in both groups. Conclusions: Abnormal trial-to-trial phase synchrony plays an important role in AEP atypicalities in children with autism. ITPC-driven enhancement as well as attenuation in different AEP components may coexist, depending on the stage of information processing. Significance: It is necessary to examine the time course of auditory evoked potentials and the corresponding inter-trial coherence of neural oscillatory activities to better understand hyper- and hypo- sensitive responses in autism, which has important implications for sensory based treatment.

AB - Objective: This autism study investigated how inter-trial phase coherence (ITPC) drives abnormalities in auditory evoked potential (AEP) responses for speech and nonspeech stimuli. Methods: Auditory P1-N2 responses and ITPCs in the theta band (4–7 Hz) for pure tones and words were assessed with EEG data from 15 school-age children with autism and 16 age-matched typically developing (TD) controls. Results: The autism group showed enhanced P1 and reduced N2 for both speech and nonspeech stimuli in comparison with the TD group. Group differences were also found with enhanced theta ITPC for P1 followed by ITPC reduction for N2 in the autism group. The ITPC values were significant predictors of P1 and N2 amplitudes in both groups. Conclusions: Abnormal trial-to-trial phase synchrony plays an important role in AEP atypicalities in children with autism. ITPC-driven enhancement as well as attenuation in different AEP components may coexist, depending on the stage of information processing. Significance: It is necessary to examine the time course of auditory evoked potentials and the corresponding inter-trial coherence of neural oscillatory activities to better understand hyper- and hypo- sensitive responses in autism, which has important implications for sensory based treatment.

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Role of inter-trial phase coherence in atypical auditory evoked potentials to speech and nonspeech stimuli in children with autism

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