Role of mitochondrial quality surveillance in myocardial infarction: From bench to bedside

Hao Zhou, Jun Ren, Sam Toan, David Mui

Research output: Contribution to journalReview articlepeer-review

Abstract

Myocardial infarction (MI) is the irreversible death of cardiomyocyte secondary to prolonged lack of oxygen or fresh blood supply. Historically considered as merely cardiomyocyte powerhouse that manufactures ATP and other metabolites, mitochondrion is recently being identified as a signal regulator that is implicated in the crosstalk and signal integration of cardiomyocyte contraction, metabolism, inflammation, and death. Mitochondria quality surveillance is an integrated network system modifying mitochondrial structure and function through the coordination of various processes including mitochondrial fission, fusion, biogenesis, bioenergetics, proteostasis, and degradation via mitophagy. Mitochondrial fission favors the elimination of depolarized mitochondria through mitophagy, whereas mitochondrial fusion preserves the mitochondrial network upon stress through integration of two or more small mitochondria into an interconnected phenotype. Mitochondrial biogenesis represents a regenerative program to replace old and damaged mitochondria with new and healthy ones. Mitochondrial bioenergetics is regulated by a metabolic switch between glucose and fatty acid usage, depending on oxygen availability. To maintain the diversity and function of mitochondrial proteins, a specialized protein quality control machinery regulates protein dynamics and function through the activity of chaperones and proteases, and induction of the mitochondrial unfolded protein response. In this review, we provide an overview of the molecular mechanisms governing mitochondrial quality surveillance and highlight the most recent preclinical and clinical therapeutic approaches to restore mitochondrial fitness during both MI and post-MI heart failure.

Original languageEnglish (US)
Article number101250
JournalAgeing Research Reviews
Volume66
DOIs
StatePublished - Mar 2021
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by grants from the National Natural Science Foundation of China (No. 81900252 , 82000537 , and 81870249 ). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Publisher Copyright:
© 2020 Elsevier B.V.

Keywords

  • Fission
  • Fusion
  • Mitochondrial quality surveillance
  • Mitophagy
  • Myocardial infarction
  • Proteostasis

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