Roles of cADPR and NAADP in pancreatic cells

Yongjuan Zhao, Richard Graeff, Hon Cheung Lee

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are Ca2-mobilizing nucleotides that were discovered in the late 1980s. Two decades of investigations have built up a considerable understanding about these two molecules that are related because both are derived from pyridine nucleotides and known to be generated by CD38/ADP-ribosyl cyclases. cADPR has been shown to target the ryanodine receptors in the endoplasmic reticulum whereas NAADP stimulates the two-pore channels in the endo-lysosomes. Accumulating results indicate that cADPR and NAADP are second messenger molecules mediating Ca2 signaling activated by a wide range of agonists. This article reviews what is known about these two molecules, especially regarding their signaling roles in the pancreatic cells.

Original languageEnglish (US)
Pages (from-to)719-729
Number of pages11
JournalActa Biochimica et Biophysica Sinica
Volume44
Issue number9
DOIs
StatePublished - Sep 2012

Keywords

  • ADP-ribosyl cyclase
  • Ca signaling
  • Ca store
  • NAADP
  • cADPR
  • pancreatic acinar cell

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