Accessory molecules expressed on T cells can mediate adhesion between T cells and other cells, or the extracellular matrix. The same T-cell accessory molecules participate in a dialogue with their ligands (counter-receptors) on the antigen-presenting cells, and elicit signals that determine the specifics of activation and subsequent differentiation of the T cells and antigen-presenting cells.
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We are thankful to Drs AA Brian, EA Clark, NK Damie, B Dupont, MK Jenkins, L Kouiova, P Kuhiman, PS Iinsiey, JA Ledbetter, P Moin-geon, C Morimoto, W Newman, RJ Noeile, and EL Reinhen for sharing with us unpublished data and papers prior to publication. The critical reading of the manuscript by Drs RE Gress and RJ Hodes is highly appreciated. GA van Seventer is a visiting associate supported by the Fogarty Exchange Program. Y Shimizu was supported by Damon-Runyon Waiter Wiicheii Cancer Research Fund Postdoctoral Fellowship DRG-993.