TY - JOUR
T1 - ROS-responsive capsules engineered from green tea polyphenol-metal networks for anticancer drug delivery
AU - Wang, Xiaoli
AU - Li, Xuanling
AU - Liang, Xiaoyu
AU - Liang, Jiayi
AU - Zhang, Chao
AU - Yang, Jing
AU - Wang, Chun
AU - Kong, Deling
AU - Sun, Hongfan
N1 - Publisher Copyright:
© The Royal Society of Chemistry 2018.
PY - 2018
Y1 - 2018
N2 - Reactive oxygen species (ROS)-responsive nanocapsules for cancer drug delivery were engineered from green tea polyphenol-metal networks. Briefly, DOX-doped ZIF-8 nanoparticles were synthesized via coprecipitation and coated with a layer of EGCG-Fe(iii) complexes by suspending in EGCG and ferric chloride aqueous solutions under mild conditions. The DOX-encapsulating EGCG/Fe nanocapsules (DOX@EGCG/Fe NCs) with a diameter of 399 nm were obtained after template removal. The as-prepared EGCG/Fe NCs can reduce ROS potential accompanied by their degradation. Moreover, DOX@EGCG/Fe NCs can be quickly internalized by cancer cells, and then the intracellular drug release was greatly accelerated in response to overproduced ROS of tumor. Owing to higher ROS levels inside tumor cells compared with normal cells, DOX@EGCG/Fe NCs cause selective cytotoxicity for tumor cells over normal cells. Furthermore, the cytotoxicity of DOX@EGCG/Fe NCs was increased with the increasing incubation time with cancer cells, whereas the tendency of free DOX was reversed. Accordingly, DOX@EGCG/Fe NCs demonstrate good tumor growth inhibition (84.2%) with minor systemic toxicity, which would be a promising candidate for B16 melanoma therapy. Hopefully, our approach could be extended to many other delivery systems such as water soluble/insoluble drugs, gene and protein due to the diversity of polyphenol-metal networks and ZIF-8 templates.
AB - Reactive oxygen species (ROS)-responsive nanocapsules for cancer drug delivery were engineered from green tea polyphenol-metal networks. Briefly, DOX-doped ZIF-8 nanoparticles were synthesized via coprecipitation and coated with a layer of EGCG-Fe(iii) complexes by suspending in EGCG and ferric chloride aqueous solutions under mild conditions. The DOX-encapsulating EGCG/Fe nanocapsules (DOX@EGCG/Fe NCs) with a diameter of 399 nm were obtained after template removal. The as-prepared EGCG/Fe NCs can reduce ROS potential accompanied by their degradation. Moreover, DOX@EGCG/Fe NCs can be quickly internalized by cancer cells, and then the intracellular drug release was greatly accelerated in response to overproduced ROS of tumor. Owing to higher ROS levels inside tumor cells compared with normal cells, DOX@EGCG/Fe NCs cause selective cytotoxicity for tumor cells over normal cells. Furthermore, the cytotoxicity of DOX@EGCG/Fe NCs was increased with the increasing incubation time with cancer cells, whereas the tendency of free DOX was reversed. Accordingly, DOX@EGCG/Fe NCs demonstrate good tumor growth inhibition (84.2%) with minor systemic toxicity, which would be a promising candidate for B16 melanoma therapy. Hopefully, our approach could be extended to many other delivery systems such as water soluble/insoluble drugs, gene and protein due to the diversity of polyphenol-metal networks and ZIF-8 templates.
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U2 - 10.1039/c7tb02688a
DO - 10.1039/c7tb02688a
M3 - Article
C2 - 32254287
AN - SCOPUS:85042157438
SN - 2050-7518
VL - 6
SP - 1000
EP - 1010
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
IS - 7
ER -