TY - JOUR
T1 - Round window membrane in Ménière's disease
T2 - A human temporal bone study
AU - Yoda, Shigetoshi
AU - Cureoglu, Sebahattin
AU - Shimizu, Shigetaka
AU - Morita, Norimasa
AU - Fukushima, Hisaki
AU - Sato, Teruyuki
AU - Harada, Tamotsu
AU - Paparella, Michael M.
PY - 2011/1
Y1 - 2011/1
N2 - Objectives: To disclose the histopathologic findings of the thickness of the round window membrane and the presence of false round window membrane in Ménière's disease. Methods: Twelve temporal bones from 6 patients with bilateral Ménière's disease, 44 temporal bones from 23 patients with unilateral Ménière's disease, and 102 age-matched normal temporal bones from 56 individuals were histopathologically examined. The thickness of the round window membrane was calculated from 3 different places. In addition, the presence of false round window membrane was investigated in temporal bones with Ménière's disease and compared to the normal temporal bones. Results: A significant difference in the mean thickness of the round window membrane was observed in temporal bones with Méniè re's disease compared with normal temporal bones. There was no significant difference in the thickness of the round window membrane between the diseased side and contralateral side in patients with unilateral Ménière's disease. A false round membrane was observed in 9 (25.7%) of 35 Ménière's disease cases and in 5 (4.9%) of 102 normal temporal bones. Conclusion: The thickened nature of the round window membrane and the frequent presence of false round window membrane in patients with Ménière's disease may impede the intratympanic injection treatments. The thickened middle layer of the round window membrane may be related to perilymphatic pressure changes observed in patients with Ménière's disease.
AB - Objectives: To disclose the histopathologic findings of the thickness of the round window membrane and the presence of false round window membrane in Ménière's disease. Methods: Twelve temporal bones from 6 patients with bilateral Ménière's disease, 44 temporal bones from 23 patients with unilateral Ménière's disease, and 102 age-matched normal temporal bones from 56 individuals were histopathologically examined. The thickness of the round window membrane was calculated from 3 different places. In addition, the presence of false round window membrane was investigated in temporal bones with Ménière's disease and compared to the normal temporal bones. Results: A significant difference in the mean thickness of the round window membrane was observed in temporal bones with Méniè re's disease compared with normal temporal bones. There was no significant difference in the thickness of the round window membrane between the diseased side and contralateral side in patients with unilateral Ménière's disease. A false round membrane was observed in 9 (25.7%) of 35 Ménière's disease cases and in 5 (4.9%) of 102 normal temporal bones. Conclusion: The thickened nature of the round window membrane and the frequent presence of false round window membrane in patients with Ménière's disease may impede the intratympanic injection treatments. The thickened middle layer of the round window membrane may be related to perilymphatic pressure changes observed in patients with Ménière's disease.
KW - Human temporal bone
KW - Ménière's disease
KW - Round window membrane
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U2 - 10.1097/MAO.0b013e318200a0e0
DO - 10.1097/MAO.0b013e318200a0e0
M3 - Article
C2 - 21131881
AN - SCOPUS:78650752404
SN - 1531-7129
VL - 32
SP - 147
EP - 151
JO - Otology and Neurotology
JF - Otology and Neurotology
IS - 1
ER -