Salivary CA130 with and without unilateral autonomic parotid denervation of rats fed different diets

Dorthea Johnson-Alvares; Germaine G Cornelissen-Guillaume; Ana Portela; Erna Halberg; Joel D Rudney; Chih Ko Yeh; Michael Dodds; Erhard Haus; Erwin Schaffer; Mikhail Blank; Franz Halberg

Salivary CA130 with and without unilateral autonomic parotid denervation of rats fed different diets

Dorthea Johnson-Alvares, Germaine G Cornelissen-Guillaume, Ana Portela, Erna Halberg, Joel D Rudney, Chih Ko Yeh, Michael Dodds, Erhard Haus, Erwin Schaffer, Mikhail Blank, Franz Halberg

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Abstract

Background. Tumor markers such as CA130 can be determined in human whole saliva. Saliva represents an attractive body fluid for longitudinal studies. Materials and methods. CA130 was determined in parotid saliva from 8 rats fed different diets, with or without autonomic denervation. Results. CA130 could be determined in parotid saliva of rats, irrespective of diet and/or autonomic denervation. Whether the numerical decrease in CA130 observed after autonomic denervation is statistically significant requires further work. Conclusions. Since salivary CA130 has been shown to decrease following treatment with anti-cancer drugs in humans, the ability to determine this tumor marker in rat saliva opens new opportunities for optimizing cancer chronotherapy in the experimental laboratory.

Original language	English (US)
Pages (from-to)	25-28
Number of pages	4
Journal	In Vivo
Volume	16
Issue number	1
State	Published - 2002

Keywords

CA130
Diet
Parotid denervation
Rat
Saliva

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title = "Salivary CA130 with and without unilateral autonomic parotid denervation of rats fed different diets",

abstract = "Background. Tumor markers such as CA130 can be determined in human whole saliva. Saliva represents an attractive body fluid for longitudinal studies. Materials and methods. CA130 was determined in parotid saliva from 8 rats fed different diets, with or without autonomic denervation. Results. CA130 could be determined in parotid saliva of rats, irrespective of diet and/or autonomic denervation. Whether the numerical decrease in CA130 observed after autonomic denervation is statistically significant requires further work. Conclusions. Since salivary CA130 has been shown to decrease following treatment with anti-cancer drugs in humans, the ability to determine this tumor marker in rat saliva opens new opportunities for optimizing cancer chronotherapy in the experimental laboratory.",

keywords = "CA130, Diet, Parotid denervation, Rat, Saliva",

author = "Dorthea Johnson-Alvares and Cornelissen-Guillaume, {Germaine G} and Ana Portela and Erna Halberg and Rudney, {Joel D} and Yeh, {Chih Ko} and Michael Dodds and Erhard Haus and Erwin Schaffer and Mikhail Blank and Franz Halberg",

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T1 - Salivary CA130 with and without unilateral autonomic parotid denervation of rats fed different diets

AU - Johnson-Alvares, Dorthea

AU - Cornelissen-Guillaume, Germaine G

AU - Portela, Ana

AU - Halberg, Erna

AU - Rudney, Joel D

AU - Yeh, Chih Ko

AU - Dodds, Michael

AU - Haus, Erhard

AU - Schaffer, Erwin

AU - Blank, Mikhail

AU - Halberg, Franz

PY - 2002

Y1 - 2002

N2 - Background. Tumor markers such as CA130 can be determined in human whole saliva. Saliva represents an attractive body fluid for longitudinal studies. Materials and methods. CA130 was determined in parotid saliva from 8 rats fed different diets, with or without autonomic denervation. Results. CA130 could be determined in parotid saliva of rats, irrespective of diet and/or autonomic denervation. Whether the numerical decrease in CA130 observed after autonomic denervation is statistically significant requires further work. Conclusions. Since salivary CA130 has been shown to decrease following treatment with anti-cancer drugs in humans, the ability to determine this tumor marker in rat saliva opens new opportunities for optimizing cancer chronotherapy in the experimental laboratory.

AB - Background. Tumor markers such as CA130 can be determined in human whole saliva. Saliva represents an attractive body fluid for longitudinal studies. Materials and methods. CA130 was determined in parotid saliva from 8 rats fed different diets, with or without autonomic denervation. Results. CA130 could be determined in parotid saliva of rats, irrespective of diet and/or autonomic denervation. Whether the numerical decrease in CA130 observed after autonomic denervation is statistically significant requires further work. Conclusions. Since salivary CA130 has been shown to decrease following treatment with anti-cancer drugs in humans, the ability to determine this tumor marker in rat saliva opens new opportunities for optimizing cancer chronotherapy in the experimental laboratory.

KW - CA130

KW - Diet

KW - Parotid denervation

KW - Rat

KW - Saliva

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Salivary CA130 with and without unilateral autonomic parotid denervation of rats fed different diets

Abstract

Keywords

UN SDGs

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