Salmonella in Swine: Microbiota Interactions

Hyeun Bum Kim, Richard E. Isaacson

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

For the important foodborne pathogen Salmonella enterica to cause disease or persist in pigs, it has evolved an intricate set of interactions between itself, the host, and the indigenous microflora of the host. S. enterica must evade the host's immune system and must also overcome colonization resistance mediated by the pig's indigenous microflora. The inflammatory response against S. enterica provides the bacteria with unique metabolites and is thus exploited by S. enterica for competitive advantage. During infection, changes in the composition of the indigenous microflora occur that have been associated with a breakdown in colonization resistance. Healthy pigs that are low-level shedders of S. enterica also exhibit alterations in their indigenous microflora similar to those in ill animals. Here we review the literature on the interactions that occur between swine, S. enterica, and the indigenous microflora and discuss methods to reduce or prevent colonization of pigs with S. enterica.

Original languageEnglish (US)
Pages (from-to)43-63
Number of pages21
JournalAnnual Review of Animal Biosciences
Volume5
DOIs
StatePublished - Feb 8 2017

Bibliographical note

Publisher Copyright:
Copyright ©2017 by Annual Reviews. All rights reserved.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

  • Control of Salmonella enterica
  • Gut
  • Health
  • Innate immunity
  • Metabolism
  • Microbiome

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