TY - JOUR
T1 - Schizo-affective disorders
T2 - bipolar-unipolar subtyping. Natural history variables: a discriminant analysis approach
AU - Van Eerdewegh, M. M.
AU - Van Eerdewegh, P.
AU - Coryell, W.
AU - Clayton, P. J.
AU - Endicott, J.
AU - Koepke, J.
AU - Rochberg, N.
N1 - Funding Information:
Supported in part by USPHS Grants MH-25430, MH-37685 and MH-31302.
PY - 1987
Y1 - 1987
N2 - In view of tackling the problem of heterogeneity among the schizo-affectives, methods of univariate and multivariate statistical analysis (canonical discriminant analysis) were applied to the sociodemographic and natural history variables of four groups of affective disorder patients from the NIMH Collaborative Study on the Psychobiology of Depression Clinical section: the schizo-bipolar (SBP, n = 45), the schizo-unipolar (SUP, n = 30), the bipolar I (BP, n = 159) and the primary unipolar depressed (UP, n = 387) defined by Research Diagnostic Criteria. Two dimensions were identified among the four groups of 'affective' patients: the 'bipolar' and the 'schizophrenic' dimensions. Theyprovided highly significant discrimination among the means of the four groups but were not very accurate in predicting group membership. The 'bipolar' dimension separates the UP from the BP and SBP, the SUP taking some intermediate value. The 'schizophrenic' dimension separates the BP and UP from the SUP, the SBP being intermediate. The two groups with the most similarities were the SBP and BP. The group with the most heterogeneity was the SUP, sharing similarities with the UP and SBP mostly. These conclusions are supported by results of familial aggregation on the same group of patients.
AB - In view of tackling the problem of heterogeneity among the schizo-affectives, methods of univariate and multivariate statistical analysis (canonical discriminant analysis) were applied to the sociodemographic and natural history variables of four groups of affective disorder patients from the NIMH Collaborative Study on the Psychobiology of Depression Clinical section: the schizo-bipolar (SBP, n = 45), the schizo-unipolar (SUP, n = 30), the bipolar I (BP, n = 159) and the primary unipolar depressed (UP, n = 387) defined by Research Diagnostic Criteria. Two dimensions were identified among the four groups of 'affective' patients: the 'bipolar' and the 'schizophrenic' dimensions. Theyprovided highly significant discrimination among the means of the four groups but were not very accurate in predicting group membership. The 'bipolar' dimension separates the UP from the BP and SBP, the SUP taking some intermediate value. The 'schizophrenic' dimension separates the BP and UP from the SUP, the SBP being intermediate. The two groups with the most similarities were the SBP and BP. The group with the most heterogeneity was the SUP, sharing similarities with the UP and SBP mostly. These conclusions are supported by results of familial aggregation on the same group of patients.
KW - (Discriminant analysis)
KW - Bipolar
KW - DSM-III
KW - Schizo-affective
KW - Schizo-depression
KW - Schizo-mania
KW - Unipolar
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U2 - 10.1016/0165-0327(87)90031-0
DO - 10.1016/0165-0327(87)90031-0
M3 - Article
C2 - 2956307
AN - SCOPUS:0023274557
SN - 0165-0327
VL - 12
SP - 223
EP - 232
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
IS - 3
ER -