TY - JOUR
T1 - Schizophrenia genetics at the millennium
T2 - Cautious optimism
AU - Gottesman, Irving I.
AU - Moldin, Steven O.
PY - 1997/11
Y1 - 1997/11
N2 - As the new millennium approaches, research into the genetic aspects of schizophrenia has already made an impressive start toward an integrated model which is discovering roles for genetic agents, environmental agents and experiences, and chance factors. The best model follows that proposed for understanding such complex diseases as coronary artery disease and diabetes. Genetic information has come from both genetic epidemiology and molecular genetics. Evidence for gene regions on 6p and 8p gives the strongest support for harboring schizophrenia susceptibility genes, based on international collaborative studies that 'generally' replicate one another; evidence for regions on 3p, 5q, 9p, 20p, and 22q, while less compelling, will encourage focused work. Determining the steps between the regions and the phenotype will challenge the next generation of scientists.
AB - As the new millennium approaches, research into the genetic aspects of schizophrenia has already made an impressive start toward an integrated model which is discovering roles for genetic agents, environmental agents and experiences, and chance factors. The best model follows that proposed for understanding such complex diseases as coronary artery disease and diabetes. Genetic information has come from both genetic epidemiology and molecular genetics. Evidence for gene regions on 6p and 8p gives the strongest support for harboring schizophrenia susceptibility genes, based on international collaborative studies that 'generally' replicate one another; evidence for regions on 3p, 5q, 9p, 20p, and 22q, while less compelling, will encourage focused work. Determining the steps between the regions and the phenotype will challenge the next generation of scientists.
KW - Epigenetic
KW - Linkage
KW - Multifactorial disease
KW - QTL
KW - Susceptibility genes
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U2 - 10.1111/j.1399-0004.1997.tb04361.x
DO - 10.1111/j.1399-0004.1997.tb04361.x
M3 - Article
C2 - 9520134
AN - SCOPUS:0031426346
SN - 0009-9163
VL - 52
SP - 404
EP - 407
JO - Clinical Genetics
JF - Clinical Genetics
IS - 5
ER -