TY - JOUR
T1 - Scientific and ethical issues related to deep brain stimulation for disorders of mood, behavior, and thought
AU - Rabins, Peter
AU - Appleby, Brian S.
AU - Brandt, Jason
AU - DeLong, Mahlon R.
AU - Dunn, Laura B.
AU - Gabriëls, Loes
AU - Greenberg, Benjamin D.
AU - Haber, Suzanne N.
AU - Holtzheimer, Paul E.
AU - Mari, Zoltan
AU - Mayberg, Helen S.
AU - McCann, Evelyn
AU - Mink, Sallie P.
AU - Rasmussen, Steven
AU - Schlaepfer, Thomas E.
AU - Vawter, Dorothy E.
AU - Vitek, Jerrold L.
AU - Walkup, John
AU - Mathews, Debra J H
PY - 2009/9
Y1 - 2009/9
N2 - Context: A 2-day consensus conference was held to examine scientific and ethical issues in the application of deep brain stimulation for treating mood and behavioral disorders, such as major depression, obsessivecompulsive disorder, and Tourette syndrome. Objectives: The primary objectives of the conference were to (1) establish consensus among participants about the design of future clinical trials of deep brain stimulation for disorders of mood, behavior, and thought and (2) develop standards for the protection of human subjects participating in such studies. Results: Conference participants identified 16 key points for guiding research in this growing field. Conclusions: The adoption of the described guidelines would help to protect the safety and rights of research subjects who participate in clinical trials of deep brain stimulation for disorders of mood, behavior, and thought and have further potential to benefit other stakeholders in the research process, including clinical researchers and device manufactures. That said, the adoption of the guidelines will require broad and substantial commitment from many of these same stakeholders.
AB - Context: A 2-day consensus conference was held to examine scientific and ethical issues in the application of deep brain stimulation for treating mood and behavioral disorders, such as major depression, obsessivecompulsive disorder, and Tourette syndrome. Objectives: The primary objectives of the conference were to (1) establish consensus among participants about the design of future clinical trials of deep brain stimulation for disorders of mood, behavior, and thought and (2) develop standards for the protection of human subjects participating in such studies. Results: Conference participants identified 16 key points for guiding research in this growing field. Conclusions: The adoption of the described guidelines would help to protect the safety and rights of research subjects who participate in clinical trials of deep brain stimulation for disorders of mood, behavior, and thought and have further potential to benefit other stakeholders in the research process, including clinical researchers and device manufactures. That said, the adoption of the guidelines will require broad and substantial commitment from many of these same stakeholders.
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U2 - 10.1001/archgenpsychiatry.2009.113
DO - 10.1001/archgenpsychiatry.2009.113
M3 - Review article
C2 - 19736349
AN - SCOPUS:69949142345
SN - 0003-990X
VL - 66
SP - 931
EP - 937
JO - Archives of General Psychiatry
JF - Archives of General Psychiatry
IS - 9
ER -