Sea-blue histiocvte associated with dosteriorl column dysfunction in childhood

Kenneth F. Swaiman, Dea Halverson, Harvey L. Sharp, Richard D. Brunning, Lawrence A. Lockman

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


1. Sea-blue histiocytes are seen in a number of clinical conditions. In our patient it appeared to be the result of storage of ceroid-lipofuscin material. 2. Sea-blue histiocytes were present in this patient with a clinical pattern of posterior column dysfunction. Untreated she had low serum vitamin E level but normal oral vitamin E uptake. 3 . The clinical picture could result from neuroaxonal dystrophy of the axons within the cuneate and gracile nuclei or from accumulation of ceroid-lipofuscin material in this area. 4. Large doses of oral vitamin E resulted in normal serum levels but did not appear to alter the stores' of ceroid-lipofuscin in bone marrow or liver.

Original languageEnglish (US)
Pages (from-to)474-477
Number of pages4
Issue number5
StatePublished - May 1973


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