Of 2895 women who self-detected an incident breast cancer that required surgery, peaks in month of detection occurred in spring and late autumn (p = 0.012). For the subset of cases for whom receptor status was available, there was a highly significant seasonal variation in detection only for those with ER-negative tumors. Further investigations into seasonality and breast cancer detection may be warranted.
Bibliographical noteFunding Information:
Supported in part by NIH training grant T32 CA09607 from the National Cancer Institute. The authors wish to thank the Atlanta Cancer Registry for providing data on estrogen-receptor status.
Data were derived solely from the Cancer and Steroid Hormone (CASH) Study. This study has been extensively described elsewhere [11–12]. Briefly, the CASH study was a population-based, case-control study coordinated by the Division of Reproductive Health, Centers for Disease Control, Atlanta, with support from the Center for Population Research at the National Institutes of Health. Enrollment of subjects began in December 1980 at collaborating Surveillance, Epidemiology, and End Results (SEER) Registries of the National Cancer Health Institute in eight areas (the metropolitan areas at Atlanta, Detroit, San Francisco, and Seattle, and the states of Connecticut, Iowa, New Mexico, and Utah).
The Cancer and Steroid Hormone Study was supported by interagency agreement 3-YO1-HD-1037 between the Centers for Disease Control and the National Institute of Child Health and Human Development, with additional support from the National Cancer Institute.
- Breast neoplasms
- Breast self-exam
- Estrogen receptors
- Seasonal variations