Sedentary time and breast cancer incidence in African American women

Sarah J.O. Nomura; Chiranjeev Dash; Lynn Rosenberg; Julie Palmer; Lucile L. Adams-Campbell

doi:10.1007/s10552-016-0803-9

Sedentary time and breast cancer incidence in African American women

Sarah J.O. Nomura, Chiranjeev Dash, Lynn Rosenberg, Julie Palmer, Lucile L. Adams-Campbell

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Purpose: The objective of this study was to evaluate whether time spent sitting at work or watching television was associated with breast cancer risk among African American women. Methods: The Black Women’s Health Study (analytic cohort = 46,734) is an ongoing prospective cohort study of African American women ages 21–69 at baseline (1995). Questionnaire data were used to estimate sedentary time. Total time spent sitting at work and watching television (individually and combined) at baseline and updated through follow-up (1995–2001) and breast cancer incidence (n = 2,041 incident cases, 1995–2013) was evaluated using proportional hazards regression. Results: Higher total time spent sitting at baseline (≥10 vs. <5 h/day, HR 1.27, 95 % CI 1.06, 1.53) and updated through follow-up (≥10 vs. <5 h/day, HR 1.38, 95 % CI 1.14, 1.66) was associated with an increased breast cancer risk. Associations were stronger for hormone receptor-negative tumors (≥10 vs. <5 h/day, HR 1.70, 95 % CI 1.12, 2.55) compared to hormone receptor-positive tumors (≥10 vs. <5 h/day, HR 1.16, 95 % CI 0.88, 1.52), but tests for heterogeneity were not statistically significant (p heterogeneity = 0.31). Positive associations between total time spent sitting and breast cancer incidence did not differ by physical activity level or body composition measurements. Conclusions: Our findings suggest that high sedentary time may increase risk for breast cancer among African American women.

Original language	English (US)
Pages (from-to)	1239-1252
Number of pages	14
Journal	Cancer Causes and Control
Volume	27
Issue number	10
DOIs	https://doi.org/10.1007/s10552-016-0803-9
State	Published - Oct 1 2016
Externally published	Yes

Bibliographical note

Funding Information:
The authors have no conflicts of interest to disclose. This work was supported by National Cancer Institute grants R01 CA058420 (L. Rosenberg) and UM1 CA164974 (L. Rosenberg). SJON is supported by National Cancer Institute training grant 5T32CA009686-19 (A. Riegel). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health. Data on breast cancer pathology were obtained from several state cancer registries (AZ, CA, CO, CT, DE, DC, FL, GA, IL, IN, KY, LA, MD, MA, MI, NJ, NY, NC, OK, PA, SC, TN, TX, VA), and results reported do not necessarily represent their views. The authors are grateful to the participants and staff of the BWHS.

Publisher Copyright:
© 2016, Springer International Publishing Switzerland.

Keywords

African American
Breast cancer
Physical activity
Sedentary time

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Sedentary time and breast cancer incidence in African American women",

abstract = "Purpose: The objective of this study was to evaluate whether time spent sitting at work or watching television was associated with breast cancer risk among African American women. Methods: The Black Women{\textquoteright}s Health Study (analytic cohort = 46,734) is an ongoing prospective cohort study of African American women ages 21–69 at baseline (1995). Questionnaire data were used to estimate sedentary time. Total time spent sitting at work and watching television (individually and combined) at baseline and updated through follow-up (1995–2001) and breast cancer incidence (n = 2,041 incident cases, 1995–2013) was evaluated using proportional hazards regression. Results: Higher total time spent sitting at baseline (≥10 vs. <5 h/day, HR 1.27, 95 % CI 1.06, 1.53) and updated through follow-up (≥10 vs. <5 h/day, HR 1.38, 95 % CI 1.14, 1.66) was associated with an increased breast cancer risk. Associations were stronger for hormone receptor-negative tumors (≥10 vs. <5 h/day, HR 1.70, 95 % CI 1.12, 2.55) compared to hormone receptor-positive tumors (≥10 vs. <5 h/day, HR 1.16, 95 % CI 0.88, 1.52), but tests for heterogeneity were not statistically significant (p heterogeneity = 0.31). Positive associations between total time spent sitting and breast cancer incidence did not differ by physical activity level or body composition measurements. Conclusions: Our findings suggest that high sedentary time may increase risk for breast cancer among African American women.",

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note = "Funding Information: The authors have no conflicts of interest to disclose. This work was supported by National Cancer Institute grants R01 CA058420 (L. Rosenberg) and UM1 CA164974 (L. Rosenberg). SJON is supported by National Cancer Institute training grant 5T32CA009686-19 (A. Riegel). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health. Data on breast cancer pathology were obtained from several state cancer registries (AZ, CA, CO, CT, DE, DC, FL, GA, IL, IN, KY, LA, MD, MA, MI, NJ, NY, NC, OK, PA, SC, TN, TX, VA), and results reported do not necessarily represent their views. The authors are grateful to the participants and staff of the BWHS. Publisher Copyright: {\textcopyright} 2016, Springer International Publishing Switzerland.",

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AU - Dash, Chiranjeev

AU - Rosenberg, Lynn

AU - Palmer, Julie

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N2 - Purpose: The objective of this study was to evaluate whether time spent sitting at work or watching television was associated with breast cancer risk among African American women. Methods: The Black Women’s Health Study (analytic cohort = 46,734) is an ongoing prospective cohort study of African American women ages 21–69 at baseline (1995). Questionnaire data were used to estimate sedentary time. Total time spent sitting at work and watching television (individually and combined) at baseline and updated through follow-up (1995–2001) and breast cancer incidence (n = 2,041 incident cases, 1995–2013) was evaluated using proportional hazards regression. Results: Higher total time spent sitting at baseline (≥10 vs. <5 h/day, HR 1.27, 95 % CI 1.06, 1.53) and updated through follow-up (≥10 vs. <5 h/day, HR 1.38, 95 % CI 1.14, 1.66) was associated with an increased breast cancer risk. Associations were stronger for hormone receptor-negative tumors (≥10 vs. <5 h/day, HR 1.70, 95 % CI 1.12, 2.55) compared to hormone receptor-positive tumors (≥10 vs. <5 h/day, HR 1.16, 95 % CI 0.88, 1.52), but tests for heterogeneity were not statistically significant (p heterogeneity = 0.31). Positive associations between total time spent sitting and breast cancer incidence did not differ by physical activity level or body composition measurements. Conclusions: Our findings suggest that high sedentary time may increase risk for breast cancer among African American women.

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Sedentary time and breast cancer incidence in African American women

Abstract

Bibliographical note

Keywords

UN SDGs

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