TY - JOUR
T1 - Sedentary time and postmenopausal breast cancer incidence
AU - Nomura, Sarah J.O.
AU - Dash, Chiranjeev
AU - Sheppard, Vanessa B.
AU - Bowen, Deborah
AU - Allison, Matthew
AU - Barrington, Wendy
AU - Chlebowski, Rowan
AU - Coday, Mace
AU - Hou, Lifang
AU - Howard, Barbara
AU - LaMonte, Michael
AU - Manson, Jo Ann E.
AU - Neuhouser, Marian L.
AU - Paskett, Electra
AU - Sattari, Maryam
AU - Stefanick, Marcia
AU - Wactawski-Wende, Jean
AU - Adams-Campbell, Lucile L.
N1 - Publisher Copyright:
© 2017, Springer International Publishing AG.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Purpose: The objective of this study was to evaluate the prospective association between sedentary time and postmenopausal breast cancer incidence, and whether associations differ by race/ethnicity, physical activity levels, and body measurements. Methods: The Women’s Health Initiative Observational Study is a prospective cohort among women ages 50–79 years at baseline (1994–1998) (analytic cohort = 70,233). Baseline questionnaire data were used to estimate time spent sitting and total sedentary time. Associations between time spent sitting and invasive breast cancer incidence overall (n = 4,115 cases through September 2015), and by hormone receptor subtypes, were investigated using Cox proportional hazards regression. Analyses were replicated stratified by race/ethnicity, body measurements, and physical activity. Results: Among women in this study, 34.5% reported ≤ 5 h/day sitting, 40.9% reported 6–9 h/day and 24.7% reported ≥ 10 h/day. Time spent sitting (≥ 10 vs. ≤5 h/day adjusted HR = 1.00, 95% CI 0.92–1.09) was not associated with breast cancer incidence, regardless of hormone receptor subtype. Associations did not differ by race/ethnicity, physical activity, or body measurements. Conclusions: Results from this study do not support an association between sedentary time and breast cancer incidence.
AB - Purpose: The objective of this study was to evaluate the prospective association between sedentary time and postmenopausal breast cancer incidence, and whether associations differ by race/ethnicity, physical activity levels, and body measurements. Methods: The Women’s Health Initiative Observational Study is a prospective cohort among women ages 50–79 years at baseline (1994–1998) (analytic cohort = 70,233). Baseline questionnaire data were used to estimate time spent sitting and total sedentary time. Associations between time spent sitting and invasive breast cancer incidence overall (n = 4,115 cases through September 2015), and by hormone receptor subtypes, were investigated using Cox proportional hazards regression. Analyses were replicated stratified by race/ethnicity, body measurements, and physical activity. Results: Among women in this study, 34.5% reported ≤ 5 h/day sitting, 40.9% reported 6–9 h/day and 24.7% reported ≥ 10 h/day. Time spent sitting (≥ 10 vs. ≤5 h/day adjusted HR = 1.00, 95% CI 0.92–1.09) was not associated with breast cancer incidence, regardless of hormone receptor subtype. Associations did not differ by race/ethnicity, physical activity, or body measurements. Conclusions: Results from this study do not support an association between sedentary time and breast cancer incidence.
KW - Body composition
KW - Breast cancer
KW - Physical activity
KW - Sedentary
KW - Sitting time
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U2 - 10.1007/s10552-017-0968-x
DO - 10.1007/s10552-017-0968-x
M3 - Article
C2 - 28975422
AN - SCOPUS:85030325571
SN - 0957-5243
VL - 28
SP - 1405
EP - 1416
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 12
ER -