Segmental duplications contribute to gene expression differences between humans and chimpanzees

Ran Blekhman, Alicia Oshlack, Yoav Gilad

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

In addition to specific changes in cis- and trans-regulatory elements, structural changes in the genome are hypothesized to underlie a large number of differences in gene expression between species. Accordingly, we show that species-specific segmental duplications are enriched with genes that are differentially expressed between humans and chimpanzees.

Original languageEnglish (US)
Pages (from-to)627-630
Number of pages4
JournalGenetics
Volume182
Issue number2
DOIs
StatePublished - Jun 2009

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