Selective Detection of Cancer Cells Using Magnetic Nanowires

Mohammad Reza Zamani Kouhpanji, Zohreh Nemati, Mohammad Mohsen Mahmoodi, Joseph Um, Jaime Modiano, Rhonda Franklin, Bethanie Stadler

Research output: Contribution to journalArticlepeer-review

Abstract

The main bottleneck for implementing magnetic nanowires (MNWs) in cell-biology research for multimodal therapeutics is the inapplicability of the current state of the art for selective detection and stimulation of MNWs. Here, we introduce a methodology for selective detection of MNWs in platforms that have multiple magnetic signals, such as future multimodal therapeutics. After characterizing the signatures of MNWs, MNWs were surface-functionalized and internalized into canine osteosarcoma (OSCA-8) cancer cells for cell labeling, manipulation, and separation. We also prepared and characterized magnetic biopolymers as multimodal platforms for future use in controlling the movement, growth, and division of cancer cells. First, it is important to have methods for distinguishing the magnetic signature of the biopolymer from the magnetically labeled cells. For this purpose, we use the projection method to selectively detect and demultiplex the magnetic signatures of MNWs inside cells from those inside magnetic biopolymers. We show that tailoring the irreversible switching field of MNWs by tuning their coercivity is a highly effective approach for generating distinct magnetic biolabels for selective detection of cancer cells. These findings open up new possibilities for selective stimulation of MNWs in multimodal therapeutic platforms for drug delivery, hyperthermia cancer therapy, and mitigating cancer cell movement and proliferation.

Original languageEnglish (US)
Pages (from-to)21060-21066
Number of pages7
JournalACS Applied Materials and Interfaces
Volume13
Issue number18
DOIs
StatePublished - May 12 2021

Bibliographical note

Funding Information:
This work is based upon work supported primarily by the National Science Foundation under grant no. CMMI-1762884. This work was also supported by the MN Futures Program of the University of Minnesota, by the Skippy Frank Fund for Life Sciences and Translational Research, by Morris Animal Foundation Grant D15CA-047, and by the Animal Cancer Care and Research Program of the University of Minnesota. Portions of this work were conducted in the Minnesota Nano Center, which is supported by the National Science Foundation through the National Nano Coordinated Infrastructure Network (NNCI) under Award Number ECCS-1542202. Part of this work was performed at the Institute for Rock Magnetism (IRM) at the University of Minnesota. The IRM is a US National Multiuser Facility supported through the Instrumentation and Facilities program of the National Science Foundation, Earth Sciences Division (NSF/EAR 1642268), and by funding from the University of Minnesota. Parts of this work were also carried out in the Characterization Facility, University of Minnesota, which receives partial support from NSF through the MRSEC program.

Publisher Copyright:
© 2021 American Chemical Society. All rights reserved.

Keywords

  • cell labeling
  • demultiplexing
  • magnetic biopolymer
  • magnetic nanowires
  • selective detection

PubMed: MeSH publication types

  • Journal Article

Fingerprint

Dive into the research topics of 'Selective Detection of Cancer Cells Using Magnetic Nanowires'. Together they form a unique fingerprint.

Cite this