Abstract
Non-viral (synthetic) nucleic acid delivery systems have the potential to provide for the practical application of nucleic acid-based therapeutics. We have designed and prepared a tunable, non-viral nucleic acid delivery system that self-assembles with nucleic acids and centers around a new class of polymeric materials; namely, linear, water-soluble cyclodextrin-containing polymers. The relationships between polymer structure and gene delivery are illustrated, and the roles of the cyclodextrin moieties for minimizing toxicity and forming inclusion complexes in the self-assembly processes are highlighted. This vehicle is the first example of a polymer-based gene delivery system formed entirely by self-assembly.
Original language | English (US) |
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Pages (from-to) | 179-197 |
Number of pages | 19 |
Journal | Current medicinal chemistry |
Volume | 11 |
Issue number | 2 |
DOIs | |
State | Published - 2004 |
Keywords
- Cyclodextrin-polymers
- Gene delivery
- Non-viral delivery
- Nucleic acid delivery
- Self-assembly
- Supramolecular structures