Self-assembly of janus dendrimers into uniform dendrimersomes and other complex architectures

Virgil Percec, Daniela A. Wilson, Pawaret Leowanawat, Christopher J. Wilson, Andrew D. Hughes, Mark S. Kaucher, Daniel A. Hammer, Dalia H. Levine, Anthony J. Kim, Frank S. Bates, Kevin P. Davis, Timothy P. Lodge, Michael L. Klein, Russell H. Devane, Emad Aqad, Brad M. Rosen, Andreea O. Argintaru, Monika J. Sienkowska, Kari Rissanen, Sami NummelinJarmo Ropponen

Research output: Contribution to journalArticlepeer-review

503 Scopus citations

Abstract

Self-assembled nanostructures obtained from natural and synthetic amphiphiles serve as mimics of biological membranes and enable the delivery of drugs, proteins, genes, and imaging agents. Yet the precise molecular arrangements demanded by these functions are difficult to achieve. Libraries of amphiphilic Janus dendrimers, prepared by facile coupling of tailored hydrophilic and hydrophobic branched segments, have been screened by cryogenic transmission electron microscopy, revealing a rich palette of morphologies in water, including vesicles, denoted dendrimersomes, cubosomes, disks, tubular vesicles, and helical ribbons. Dendrimersomes marry the stability and mechanical strength obtainable from polymersomes with the biological function of stabilized phospholipid liposomes, plus superior uniformity of size, ease of formation, and chemical functionalization. This modular synthesis strategy provides access to systematic tuning of molecular structure and of self-assembled architecture.

Original languageEnglish (US)
Pages (from-to)1009-1014
Number of pages6
JournalScience
Volume328
Issue number5981
DOIs
StatePublished - May 21 2010

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