Self-reported medical conditions in perfluorooctanesulfonyl fluoride manufacturing workers

Mira M. Grice, Bruce H Alexander, Richard Hoffbeck, Diane M. Kampa

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

OBJECTIVE: To evaluate whether some cancers, other conditions, and pregnancy outcomes were related to occupational perfluorooctane sulfonate (PFOS) exposure. METHODS: We surveyed current and former employees of a perfluorooctanesulfonyl fluoride production facility, using a self-administered questionnaire to ascertain several cancers and health conditions. Female cohort members also completed a brief pregnancy history. We requested medical records to validate reported melanoma, breast, prostate, and colon cancers. PFOS exposure was estimated based on a job exposure matrix up to the year of the diagnosis of the condition. RESULTS: Of the 1895 eligible participants, 1400 questionnaires were returned. No association was observed between working in a PFOS-exposed job and the risk of any of the surveyed conditions. CONCLUSION: We observed no association between working in a PFOS-exposed job and several cancers, common health conditions, and birth weight.

Original languageEnglish (US)
Pages (from-to)722-729
Number of pages8
JournalJournal of occupational and environmental medicine
Volume49
Issue number7
DOIs
StatePublished - Jul 1 2007

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