Semisynthesis and biological evaluation of brevifoliol 13-[N-benzoyl-(-2′R,3′S)-3′-phenylisoserinate]

Gunda I. Georg; Zacharia S. Cheruvallath; David Vander Velde; Qing Mei Ye; Lester A. Mitscher; Richard H. Himes

doi:10.1016/S0960-894X(00)80346-7

Semisynthesis and biological evaluation of brevifoliol 13-[N-benzoyl-(-2′R,3′S)-3′-phenylisoserinate]

Gunda I. Georg, Zacharia S. Cheruvallath, David Vander Velde, Qing Mei Ye, Lester A. Mitscher, Richard H. Himes

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

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Abstract

Coupling between brevifoliol (1) and β-lactam (2) yielded, after protecting group removal, brevifoliol 13-[N-benzoyl-(2′R,3′S)-3′-phenylisoserinate] (3). This novel taxol analogue was found to be inactive in the microtubule binding assay and had little cytotoxicity against B16 melanoma cells.

Original language	English (US)
Pages (from-to)	1349-1350
Number of pages	2
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	3
Issue number	6
DOIs	https://doi.org/10.1016/S0960-894X(00)80346-7
State	Published - Jun 1993

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title = "Semisynthesis and biological evaluation of brevifoliol 13-[N-benzoyl-(-2′R,3′S)-3′-phenylisoserinate]",

abstract = "Coupling between brevifoliol (1) and β-lactam (2) yielded, after protecting group removal, brevifoliol 13-[N-benzoyl-(2′R,3′S)-3′-phenylisoserinate] (3). This novel taxol analogue was found to be inactive in the microtubule binding assay and had little cytotoxicity against B16 melanoma cells.",

author = "Georg, {Gunda I.} and Cheruvallath, {Zacharia S.} and Velde, {David Vander} and Ye, {Qing Mei} and Mitscher, {Lester A.} and Himes, {Richard H.}",

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language = "English (US)",

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AU - Georg, Gunda I.

AU - Cheruvallath, Zacharia S.

AU - Velde, David Vander

AU - Ye, Qing Mei

AU - Mitscher, Lester A.

AU - Himes, Richard H.

PY - 1993/6

Y1 - 1993/6

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AB - Coupling between brevifoliol (1) and β-lactam (2) yielded, after protecting group removal, brevifoliol 13-[N-benzoyl-(2′R,3′S)-3′-phenylisoserinate] (3). This novel taxol analogue was found to be inactive in the microtubule binding assay and had little cytotoxicity against B16 melanoma cells.

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IS - 6

ER -

Semisynthesis and biological evaluation of brevifoliol 13-[N-benzoyl-(-2′R,3′S)-3′-phenylisoserinate]

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