Semisynthesis and biological evaluation of brevifoliol 13-[N-benzoyl-(-2′R,3′S)-3′-phenylisoserinate]

Gunda I. Georg, Zacharia S. Cheruvallath, David Vander Velde, Qing Mei Ye, Lester A. Mitscher, Richard H. Himes

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Coupling between brevifoliol (1) and β-lactam (2) yielded, after protecting group removal, brevifoliol 13-[N-benzoyl-(2′R,3′S)-3′-phenylisoserinate] (3). This novel taxol analogue was found to be inactive in the microtubule binding assay and had little cytotoxicity against B16 melanoma cells.

Original languageEnglish (US)
Pages (from-to)1349-1350
Number of pages2
JournalBioorganic and Medicinal Chemistry Letters
Issue number6
StatePublished - Jun 1993

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