Sensing and Regulating Synaptic Activity by Astrocytes at Tripartite Synapse

José Antonio Noriega-Prieto; Alfonso Araque

doi:10.1007/s11064-021-03317-x

Sensing and Regulating Synaptic Activity by Astrocytes at Tripartite Synapse

José Antonio Noriega-Prieto, Alfonso Araque

Neuroscience

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Astrocytes are recognized as more important cells than historically thought in synaptic function through the reciprocal exchange of signaling with the neuronal synaptic elements. The idea that astrocytes are active elements in synaptic physiology is conceptualized in the Tripartite Synapse concept. This review article presents and discusses recent representative examples that highlight the heterogeneity of signaling in tripartite synapse function and its consequences on neural network function and animal behavior.

Original language	English (US)
Pages (from-to)	2580-2585
Number of pages	6
Journal	Neurochemical Research
Volume	46
Issue number	10
DOIs	https://doi.org/10.1007/s11064-021-03317-x
State	Published - Oct 2021

Bibliographical note

Funding Information:
This work was supported by National Institute of Neurological Disorders and Stroke [Grant No. R01NS097312] and National Institute on Drug Abuse [Grant No. R01DA048822]. National Institute of Mental Health [Grant No R01MH119355].

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

Astrocytes
Gliotransmission
Network function
Synaptic function
Tripartite synapse

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Sensing and Regulating Synaptic Activity by Astrocytes at Tripartite Synapse

Abstract

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Keywords

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