Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β

Henrique Borges da Silva; Changwei Peng; Haiguang Wang; Kelsey M. Wanhainen; Chaoyu Ma; Sharon Lopez; Alexander Khoruts; Nu Zhang; Stephen C. Jameson

doi:10.1016/j.immuni.2020.06.010

Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8⁺ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β

Henrique Borges da Silva, Changwei Peng, Haiguang Wang, Kelsey M. Wanhainen, Chaoyu Ma, Sharon Lopez, Alexander Khoruts, Nu Zhang, Stephen C. Jameson

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Borges da Silva et al. report that the extracellular ATP receptor P2RX7 promotes generation of virus-specific tissue-resident memory (Trm) CD8⁺ T cells through induction of the TGF-β signaling pathway. Furthermore, long-term maintenance of Trm cells relies on continuous P2RX7 signaling.

Original language	English (US)
Pages (from-to)	158-171.e6
Journal	Immunity
Volume	53
Issue number	1
DOIs	https://doi.org/10.1016/j.immuni.2020.06.010
State	Published - Jul 14 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc.

Keywords

P2RX7
TGF-β
eATP
memory CD8 T cells
non-lymphoid tissue

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.immuni.2020.06.010

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Cite this

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title = "Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β",

abstract = "Borges da Silva et al. report that the extracellular ATP receptor P2RX7 promotes generation of virus-specific tissue-resident memory (Trm) CD8+ T cells through induction of the TGF-β signaling pathway. Furthermore, long-term maintenance of Trm cells relies on continuous P2RX7 signaling.",

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AU - Wang, Haiguang

AU - Wanhainen, Kelsey M.

AU - Ma, Chaoyu

AU - Lopez, Sharon

AU - Khoruts, Alexander

AU - Zhang, Nu

AU - Jameson, Stephen C.

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