Sensing, signaling, and secretion: A review and analysis of systems for regulating host interaction in wolbachia

Research output: Contribution to journalReview articlepeer-review

Abstract

Wolbachia (Anaplasmataceae) is an endosymbiont of arthropods and nematodes that resides within host cells and is well known for manipulating host biology to facilitate transmission via the female germline. The effects Wolbachia has on host physiology, combined with reproductive manipulations, make this bacterium a promising candidate for use in biological-and vector-control. While it is becoming increasingly clear that Wolbachia’s effects on host biology are numerous and vary according to the host and the environment, we know very little about the molecular mechanisms behind Wolbachia’s interactions with its host. Here, I analyze 29 Wolbachia genomes for the presence of systems that are likely central to the ability of Wolbachia to respond to and interface with its host, including proteins for sensing, signaling, gene regulation, and secretion. Second, I review conditions under which Wolbachia alters gene expression in response to changes in its environment and discuss other instances where we might hypothesize Wolbachia to regulate gene expression. Findings will direct mechanistic investigations into gene regulation and host-interaction that will deepen our understanding of intracellular infections and enhance applied management efforts that leverage Wolbachia.

Original languageEnglish (US)
Article number813
Pages (from-to)1-21
Number of pages21
JournalGenes
Volume11
Issue number7
DOIs
StatePublished - Jul 2020

Bibliographical note

Funding Information:
Funding: ARIL was supported in part by the National Institutes of Health (R01AI144430 to Irene Newton), and the APC was funded by a generous startup grant from the Agricultural Research, Education and Extension Tech Transfer program (AGREETT) to ARIL at the University of Minnesota.

Publisher Copyright:
© 2020 by the author. Licensee MDPI, Basel, Switzerland.

Keywords

  • Endosymbiont
  • Environmental response
  • Gene regulation
  • Symbiosis
  • Transcriptional regulation
  • Two-component system
  • Type I secretion system
  • Type IV secretion system

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

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