Sensitization of cat dorsal horn neurons to innocuous mechanical stimulation after intradermal injection of capsaicin

Donald A. Simone; Thomas K. Baumann; J. G. Collins; Robert H. LaMotte

doi:10.1016/0006-8993(89)91293-6

Sensitization of cat dorsal horn neurons to innocuous mechanical stimulation after intradermal injection of capsaicin

Donald A. Simone, Thomas K. Baumann, J. G. Collins, Robert H. LaMotte

Diagnostic and Biological Sciences

Research output: Contribution to journal › Article › peer-review

127 Scopus citations

Abstract

Intradermal injection of 100 μg of capsaicin in cats excited dorsal horn spinal neurons classified as either 'high threshold' or 'wide dynamic range'. Capsaicin enhanced their responses to innocuous mechanical stimulation. A role for these neurons in mechanical hyperalgesia is suggested.

Original language	English (US)
Pages (from-to)	185-189
Number of pages	5
Journal	Brain Research
Volume	486
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(89)91293-6
State	Published - May 1 1989

Bibliographical note

Funding Information:
Supported in part by NIH Training Grant NS-07968 (to D.A.S.) and NIH Grants NS-14624 (to R.H.L.) and NS-23033 (to J.G.C.).

Keywords

Capsaicin
Dorsal horn neuron
Mechanical hyperalgesia
Pain

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title = "Sensitization of cat dorsal horn neurons to innocuous mechanical stimulation after intradermal injection of capsaicin",

abstract = "Intradermal injection of 100 μg of capsaicin in cats excited dorsal horn spinal neurons classified as either 'high threshold' or 'wide dynamic range'. Capsaicin enhanced their responses to innocuous mechanical stimulation. A role for these neurons in mechanical hyperalgesia is suggested.",

keywords = "Capsaicin, Dorsal horn neuron, Mechanical hyperalgesia, Pain",

author = "Simone, {Donald A.} and Baumann, {Thomas K.} and Collins, {J. G.} and LaMotte, {Robert H.}",

note = "Funding Information: Supported in part by NIH Training Grant NS-07968 (to D.A.S.) and NIH Grants NS-14624 (to R.H.L.) and NS-23033 (to J.G.C.).",

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AU - Simone, Donald A.

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AU - Collins, J. G.

AU - LaMotte, Robert H.

N1 - Funding Information: Supported in part by NIH Training Grant NS-07968 (to D.A.S.) and NIH Grants NS-14624 (to R.H.L.) and NS-23033 (to J.G.C.).

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Y1 - 1989/5/1

N2 - Intradermal injection of 100 μg of capsaicin in cats excited dorsal horn spinal neurons classified as either 'high threshold' or 'wide dynamic range'. Capsaicin enhanced their responses to innocuous mechanical stimulation. A role for these neurons in mechanical hyperalgesia is suggested.

AB - Intradermal injection of 100 μg of capsaicin in cats excited dorsal horn spinal neurons classified as either 'high threshold' or 'wide dynamic range'. Capsaicin enhanced their responses to innocuous mechanical stimulation. A role for these neurons in mechanical hyperalgesia is suggested.

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KW - Pain

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ER -

Sensitization of cat dorsal horn neurons to innocuous mechanical stimulation after intradermal injection of capsaicin

Abstract

Bibliographical note

Keywords

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