Sensitization of nociceptors by prostaglandin E₂-glycerol contributes to hyperalgesia in mice with sickle cell disease

Medicine & Life Sciences

• Nociceptors 99%
• Sickle Cell Anemia 88%
• Hyperalgesia 87%
• Glycerol 84%
• Dinoprostone 78%
• Flurbiprofen 58%
• hemoglobin AA 33%
• glyceryl 2-arachidonate 29%
• Pain 23%
• Diagnosis-Related Groups 23%
• Cyclooxygenase 2 21%
• purinoceptor P2Y6 17%
• Sickle Hemoglobin 14%
• Endocannabinoids 12%
• Spinal Ganglia 10%
• Sensory Receptor Cells 10%
• Prostaglandin-Endoperoxide Synthases 10%
• Chronic Pain 9%
• Transgenic Mice 9%
• Opioid Analgesics 8%
• Spinal Cord 8%
• Aptitude 6%
• Inflammation 5%
• Injections 5%
• Skin 5%

Chemical Compounds

• (R)-Flurbiprofen 100%
• Prostaglandin 91%
• Sensitization 85%
• 2-Arachidonoylglycerol 44%
• Prostaglandin E2 36%
• Endocannabinoid 20%
• Cord 16%
• Agent Interacting With Transmitter, Hormone or Drug Receptor 14%
• Arachidonic Acid 14%
• Hemoglobin 12%
• Dose 10%
• Block Like Crystal 9%