Sequence distribution of nucleobase adducts studied by isotope labeling of DNA–MASS spectrometry

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

The formation of covalent nucleobase lesions (DNA adducts) is the first critical step of chemical carcinogenesis.1 If not repaired, DNA adducts can cause mispairing during DNA replication and be converted to heritable mutations. Accumulation of genetic changes in tumor suppressor genes and protooncogenes is a hallmark of cancer.2

Original languageEnglish (US)
Title of host publicationMass Spectrometry of Nucleosides and Nucleic Acids
PublisherCRC Press
Pages257-282
Number of pages26
ISBN (Electronic)9781420044034
ISBN (Print)9781420044027
DOIs
StatePublished - Jan 1 2009

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