Sequence of raccoon IAPP supports importance of a specific structural motif in the development of pancreatic islet amyloidosis

Kathryn C. Jordan, Timothy D. O'brien, Kenneth H. Johnson

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The amino acid sequence of raccoon islet amyloid polypeptide (IAPP), as predicted by analysis of polymerase chain reaction (PCR)-amplified sequences from genomic DNA, contains the same putative amyloidogenic sequence (GAILS) at residues 24-28 as human and cat IAPP. These findings are consistent with evidence that the occurrence of islet amyloidosis, usually in association with age-associated (type 2) diabetes, is limited to a few unique species (e.g., humans, cats, raccoons) that produce IAPP molecules containing an inherent amyloidogenic structural motif. Although the presence of an intrinsic amyloidogenic structural motif within the IAPP molecule appears to be a prerequisite for the development of this form of amyloidosis, it is increasingly clear that additional factors are importantly involved in the ultimate expression of IAPP fibrillogenesis and deposition as islet amyloid deposits.

Original languageEnglish (US)
Pages (from-to)160-164
Number of pages5
JournalAmyloid
Volume1
Issue number3
DOIs
StatePublished - 1994

Bibliographical note

Funding Information:
This study was supported by Grant RO1 DK36734 of the National Institute of Diabetes and Digestive and Kidney Disease, and the Mr. and Mrs. George W. Taylor Foundation.

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

  • Amylix
  • Amyloid
  • Diabetes melutus
  • Islet amyloid polypeptide (Iapp)
  • Polymerase chain reaction

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