The dipeptide seryl-histidine (Ser-His) catalyses the condensation of esters of amino acids, peptide fragments, and peptide nucleic acid (PNA) building blocks, bringing to the formation of peptide bonds. Di-, tri- or tetra-peptides can be formed with yields that vary from 0.5% to 60% depending on the nature of the substrate and on the conditions. Other simpler peptides as Gly-Gly, or Gly-Gly-Gly are also effective, although less efficiently. We discuss the results from the viewpoint of primitive chemistry and the origin of long macromolecules by stepwise fragment condensations.
Bibliographical noteFunding Information:
Research conducted in the P.L.L.’s laboratory (Chemical Synthetic Biology) is supported by the EC FP6 (contract #043359), the Human Frontier Science Program, and the Italian Space Agency.
- Fragment condensation
- Origins of life
- Peptide condensation
- Prebiotic chemistry