Abstract
This study indicates that sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA) overexpression may be an effective approach to targeting cardiac microvascular ischemia/reperfusion injury by regulating calcium/XO/ROS signaling and preserving mitochondrial quality control.
Original language | English (US) |
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Pages (from-to) | 696-707 |
Number of pages | 12 |
Journal | Molecular Therapy - Nucleic Acids |
Volume | 22 |
DOIs | |
State | Published - Dec 4 2020 |
Bibliographical note
Publisher Copyright:© 2020 The Authors
Keywords
- ROS
- SERCA
- XO
- cardiac microvascular I/R injury
- mitochondrial quality control