Serotonergic Stimulation of Prolactin Secretion Is Inhibited by Vasoactive Intestinal Peptide Immunoneutralization in the Turkey

M. E. El Halawani; O. M. Youngren; J. Rozenboim; G. R. Pitts; J. L. Silsby; R. E. Phillips

doi:10.1006/gcen.1995.1086

Serotonergic Stimulation of Prolactin Secretion Is Inhibited by Vasoactive Intestinal Peptide Immunoneutralization in the Turkey

M. E. El Halawani, O. M. Youngren, J. Rozenboim, G. R. Pitts, J. L. Silsby, R. E. Phillips

Animal Science

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26 Scopus citations

Abstract

The neuronal mechanisms that govern prolactin (PRL) secretion in the turkey appear to involve monoaminergic systems. Considerable evidence indicates that serotonin (5-HT), acting centrally, is a potent stimulator of PRL secretion. This study, using birds actively immunized against VIP, tests the hypothesis that 5-HT stimulates PRL secretion by releasing vasoactive intestinal peptide (VIP). Nonimmunized turkeys were injected ip with saline, quipazine (5-HT agonist; 5 mg/kg), methysergide (5-HT antagonist; 8 mg/kg), or methysergide plus quipazine, and VIP-immunized birds were injected with saline or quipazine. Quipazine increased plasma PRL levels from 26.8 ± 7.1 ng/ml at Time 0 to a peak value of 148.1 ± 31.4 ng/ml 2 hr after injection. Pretreatment with methysergide or VIP-immunoneutralization abolished the PRL response to quipazine. Intraventricular infusion of 5-HT (1 nmol/min) caused plasma PRL to rise from a baseline of 16.3 ± 2.6 ng/ml to 85.2 ± 14.3 ng/ml after 30 min in nonimmunized control birds. Serotonin infusion did not induce PRL secretion in the VIP immunized birds. These findings suggest that serotonergic stimulation of PRL secretion in the female turkey requires a functional VIPergic system.

Original language	English (US)
Pages (from-to)	69-74
Number of pages	6
Journal	General and Comparative Endocrinology
Volume	99
Issue number	1
DOIs	https://doi.org/10.1006/gcen.1995.1086
State	Published - Jul 1995

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title = "Serotonergic Stimulation of Prolactin Secretion Is Inhibited by Vasoactive Intestinal Peptide Immunoneutralization in the Turkey",

abstract = "The neuronal mechanisms that govern prolactin (PRL) secretion in the turkey appear to involve monoaminergic systems. Considerable evidence indicates that serotonin (5-HT), acting centrally, is a potent stimulator of PRL secretion. This study, using birds actively immunized against VIP, tests the hypothesis that 5-HT stimulates PRL secretion by releasing vasoactive intestinal peptide (VIP). Nonimmunized turkeys were injected ip with saline, quipazine (5-HT agonist; 5 mg/kg), methysergide (5-HT antagonist; 8 mg/kg), or methysergide plus quipazine, and VIP-immunized birds were injected with saline or quipazine. Quipazine increased plasma PRL levels from 26.8 ± 7.1 ng/ml at Time 0 to a peak value of 148.1 ± 31.4 ng/ml 2 hr after injection. Pretreatment with methysergide or VIP-immunoneutralization abolished the PRL response to quipazine. Intraventricular infusion of 5-HT (1 nmol/min) caused plasma PRL to rise from a baseline of 16.3 ± 2.6 ng/ml to 85.2 ± 14.3 ng/ml after 30 min in nonimmunized control birds. Serotonin infusion did not induce PRL secretion in the VIP immunized birds. These findings suggest that serotonergic stimulation of PRL secretion in the female turkey requires a functional VIPergic system.",

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Serotonergic Stimulation of Prolactin Secretion Is Inhibited by Vasoactive Intestinal Peptide Immunoneutralization in the Turkey

Abstract

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