SERS Detection of Ricin B-Chain via N-Acetyl-Galactosamine Glycopolymers

Victoria M. Szlag, Matthew J. Styles, Lindsey R. Madison, Antonio R. Campos, Bharat Wagh, Dustin Sprouse, George C. Schatz, Theresa M. Reineke, Christy L. Haynes

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

A novel sensing scheme is exemplified through the detection of ricin B-chain (RBC) in water and liquid food matrices: surface-enhanced Raman spectroscopy (SERS) coupled with an N-acetyl-galactosamine glycopolymer capture layer. The sensing scheme's detection limit was well below that of the predicted oral exposure limit. Theoretical predictions of the normal Raman spectrum of the glycomonomer give insight into polymer-RBC intermolecular interactions.

Original languageEnglish (US)
Pages (from-to)842-846
Number of pages5
JournalACS Sensors
Volume1
Issue number7
DOIs
StatePublished - Jul 22 2016

Bibliographical note

Funding Information:
This work was partially supported by the National Science Foundation through the University of Minnesota Materials Science Research and Engineering Center (DMR-1420013). Parts of this work were carried out in the College of Science & Engineering Characterization Facility University of Minnesota, which receives partial support from NSF through the MRSEC program. The SEM images were taken in the University of Minnesota I.T. Characterization Facility, which receives partial support from NSF through the NNIN program. L.R.M. and G.C.S. acknowledge supported from the NSF GRFP under Grant DGE-1324585 and by the MRSEC program at Northwestern University under Award DMR-1121262. We thank Zhe Gao for her assistance with the SEM images.

Keywords

  • DFT modeling
  • film over nanospheres
  • glycopolymers
  • ricin
  • surface-enhanced raman spectroscopy

How much support was provided by MRSEC?

  • Partial

Reporting period for MRSEC

  • Period 3

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