Nutritional intakes, transthyretin (preal, bumin) levels, and anthropometric measurements were measured weekly in 26 preterm infants from week 2 of life throughout hospitalization. A sustained significant increase in protein intake occurred in 14 infants over a 2, week period. When mean protein intake increased, mean transthyretin levels increased during the same week (p < 0.001), followed 1 week later by significant increases in mean weight, occipitofrontal head circumference (OFC), and mid, arm circumference (MAC). In the other 12 infants, a sustained significant decrease in protein intake occurred over 2 weeks. When mean protein intake decreased (p < 0.01), transthyretin levels decreased during the same week (p < 0.05), followed I week later by signif, icant decreases in mean weight and MAC growth. Over all hospitalization weeks (n = 95), rates of weight gain were more significantly associated with previous trends in transthyretin levels (p = 0.007) than with protein intake alone (p = 0.08). In particular, declines in rates of weight gain were predicted significantly more frequently by the prior week’s transthyretin trend (70%) than by the trend in protein intake (47%). In growing premature infants, changes in transthyretin levels occur 1 week before changes in anthropometric measurements. Changes in transthyretin levels are more predictive than changes in protein intake alone for monitoring growth velocity in preterm infants.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of pediatric gastroenterology and nutrition|
|State||Published - Jan 1 1987|
- Preterm infants
- Protein intake