Purpose: Approximately half of previous studies on serum uric acid have reported it to be an independent risk factor for coronary heart disease (CHD). We tested this hypothesis in the Atherosclerosis Risk in Communities (ARIC) Study. Methods: A total of 13,504 healthy middle-aged men and women were followed prospectively for up to eight years. We identified 128 fatal and nonfatal CHD events in women and 264 in men. Results: The age-, race-, and ARIC field center-adjusted relative risk of CHD for sex-specific quartiles of serum uric acid were 1.0, 1.39, 1.08, and 2.35 in women (p for trend = 0.009) and 1.0, 1.03, 0.89, and 1.21 in men (p for trend = 0.44), respectively. However, serum uric acid was correlated positively with many risk factors, and after multivariable adjustment, there was little evidence of an association of uric acid with CHD in either sex. Conclusions: Our results are not consistent with serum uric acid being an independent risk factor for CHD. Copyright (C) 2000 Elsevier Science Inc.
Bibliographical noteFunding Information:
This research was supported by contracts N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021, and N01-HC-55022 from the U.S. National Heart, Lung, and Blood Institute. The authors thank Lori Boland for programming assistance, and the following staff of the ARIC Study: Phyllis Johnson, Marilyn Knowles, and Catherine Paton from the University of North Carolina, Chapel Hill, NC; Shirley Cothern, Amy Haire, Kim Jones, and Delilah Posey from the University of North Carolina, Forsyth County, NC; Betty Warren, Dorothy Washington, Mattye Watson, and Nancy Wilson from the University of Mississippi Medical Center, Jackson, MS; Amy Shomshak, LaVonne Sjoberg, Margaret Skelton, and Rita Smith from the University of Minnesota, Minneapolis, MN; Dorothy Nixon, Thelma Oliver, Rodney Palmer, and Patricia Slagle from the Johns Hopkins University, Baltimore, MD; Valarie Stinson, Pam Pfile, Hogan Pham, and Teri Trevino from the University of Texas Medical School, Houston, TX; Wanda Alexander, Doris Harper, Charles Rhodes, and Selma Soyal from the Methodist Hospital, Atherosclerosis Clinical Laboratory, Houston, TX; Anne Safrit, Melanie Wilder, Linda Allred, and Carolyn Bell from the Bowman-Gray School of Medicine, Ultrasound Reading Center, Winston-Salem, NC; and Myra Carpenter, Limin Clegg, Peter DeSaix, and Thomas Goodwin from the ARIC Coordinating Center, University of North Carolina, Chapel Hill, NC.
- Coronary Disease
- Prospective Study
- Uric Acid