TY - JOUR
T1 - Serum uric acid in hypertensive patients with and without peripheral arterial disease
AU - Langlois, Michel
AU - De Bacquer, Dirk
AU - Duprez, Daniel
AU - De Buyzere, Marc
AU - Delanghe, Joris
AU - Blaton, Victor
N1 - Funding Information:
Michel Langlois is recipient of a postdoctoral fellowship of the Fund for Scientific Research (FWO), Flanders, Belgium.
PY - 2003/5/1
Y1 - 2003/5/1
N2 - Background: Uric acid is frequently elevated in hypertension. In addition to renal and metabolic disturbances, lower limb ischemia might contribute to hyperuricemia among hypertensives complicated by peripheral arterial disease (PAD). Objective: To test the hypothesis that uric acid status is related to lower limb function in hypertensives with PAD. Methods: Serum and 24-h urine uric acid levels and other risk factors were examined in 145 hypertensives free of PAD and 166 hypertensives with PAD. Ankle/brachial index (ABI) and absolute claudication distance (in PAD) on a treadmill test (ACD) were assessed. Results: In multiple regression analysis for serum uric acid in the total group, PAD emerged as an independent determinant (P=0.03) next to age (P=0.005), triglycerides (P=0.04), and insulin (P=0.02). Serum uric acid concentrations were higher in hypertensives with PAD (404±101 vs. 347±80 μmol/l, P<0.001) independent of components of the metabolic syndrome (body mass index, triglycerides, insulin) and of age, gender, diabetes mellitus, pulse pressure, cholesterol, C-reactive protein, and treatment. After adjustment for kidney function by uric acid/creatinine ratio, values remained higher in hypertensives with PAD (P=0.01). Uric acid excretion was higher in the PAD group (P<0.001), whereas uric acid clearance was comparable between both groups. In multiple regression analysis for ACD (357±183 m) in the PAD group, serum uric acid (P=0.02), C-reactive protein (P<0.0001), age (P=0.02), and smoking (P=0.004) were independently associated. ABI (0.62±0.17) was not related to uric acid in PAD patients. Conclusion: Hyperuricemia is more pronounced in hypertensives complicated by PAD and is associated with worse functional status of the peripheral circulation.
AB - Background: Uric acid is frequently elevated in hypertension. In addition to renal and metabolic disturbances, lower limb ischemia might contribute to hyperuricemia among hypertensives complicated by peripheral arterial disease (PAD). Objective: To test the hypothesis that uric acid status is related to lower limb function in hypertensives with PAD. Methods: Serum and 24-h urine uric acid levels and other risk factors were examined in 145 hypertensives free of PAD and 166 hypertensives with PAD. Ankle/brachial index (ABI) and absolute claudication distance (in PAD) on a treadmill test (ACD) were assessed. Results: In multiple regression analysis for serum uric acid in the total group, PAD emerged as an independent determinant (P=0.03) next to age (P=0.005), triglycerides (P=0.04), and insulin (P=0.02). Serum uric acid concentrations were higher in hypertensives with PAD (404±101 vs. 347±80 μmol/l, P<0.001) independent of components of the metabolic syndrome (body mass index, triglycerides, insulin) and of age, gender, diabetes mellitus, pulse pressure, cholesterol, C-reactive protein, and treatment. After adjustment for kidney function by uric acid/creatinine ratio, values remained higher in hypertensives with PAD (P=0.01). Uric acid excretion was higher in the PAD group (P<0.001), whereas uric acid clearance was comparable between both groups. In multiple regression analysis for ACD (357±183 m) in the PAD group, serum uric acid (P=0.02), C-reactive protein (P<0.0001), age (P=0.02), and smoking (P=0.004) were independently associated. ABI (0.62±0.17) was not related to uric acid in PAD patients. Conclusion: Hyperuricemia is more pronounced in hypertensives complicated by PAD and is associated with worse functional status of the peripheral circulation.
KW - Atherosclerosis
KW - Claudication
KW - Hypertension
KW - Peripheral vascular disease
KW - Risk factors
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U2 - 10.1016/S0021-9150(03)00093-5
DO - 10.1016/S0021-9150(03)00093-5
M3 - Article
C2 - 12732400
AN - SCOPUS:0038741991
SN - 0021-9150
VL - 168
SP - 163
EP - 168
JO - Atherosclerosis
JF - Atherosclerosis
IS - 1
ER -