Sesquiterpenoids Isolated from Two Species of the Asteriscus Alliance

Jorge Triana, José Luis Eiroa, Manuel Morales, Francisco J. Perez, Ignacio Brouard, José Quintana, Mercedes Ruiz-Estévez, Francisco Estévez, Francisco León

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Investigation of the aerial parts of two Spanish members of the Asteriscus alliance, Asteriscus graveolens subsp. stenophyllus and Asteriscus schultzii, afforded four new sesquiterpene lactones containing a humulene skeleton (1-4) and one new sesquiterpene lactone of the asteriscanolide type (5). Their chemical structures were determined on the basis of the HRMS and from 1D and 2D NMR spectroscopic studies. Both species showed different profiles of sesquiterpenoid constituents. A. schultzii did not show humulene or asteriscane sesquiterpenes, suggesting a resemblance to the genus Pallenis, another member of the Asteriscus alliance. A literature review on chemical isolates from the Asteriscus alliance supported the placement of A. schultzii in the genus Pallenis. The isolated components (1-5) were assessed for cytotoxicity against the HL-60 and MOLT-3 leukemia cell lines, with compound 1 showing activity in both biological assays (IC50 value range 4.1-5.4 M).

Original languageEnglish (US)
Pages (from-to)1292-1297
Number of pages6
JournalJournal of Natural Products
Volume79
Issue number5
DOIs
StatePublished - May 27 2016

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